TY - JOUR
T1 - Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease
AU - Frederiksen, Kristian Steen
AU - Jensen, Camilla Steen
AU - Høgh, Peter
AU - Gergelyffy, Robert
AU - Waldemar, Gunhild
AU - Andersen, Birgitte Bo
AU - Gottrup, Hanne
AU - Vestergaard, Karsten
AU - Wermuth, Lene
AU - Søndergaard, Helle Bach
AU - Sellebjerg, Finn
AU - Hasselbalch, Steen Gregers
AU - Simonsen, Anja Hviid
N1 - Copyright © 2023 Frederiksen, Jensen, Høgh, Gergelyffy, Waldemar, Andersen, Gottrup, Vestergaard, Wermuth, Søndergaard, Sellebjerg, Hasselbalch and Simonsen.
PY - 2023/1/24
Y1 - 2023/1/24
N2 - INTRODUCTION: Aerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.OBJECTIVE: To investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer's disease (AD).METHODS: This is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer's disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention.RESULTS: A total of 136 participants were included in the analysis. Groups were comparable at baseline except for APOEε4 carriership which was higher in the usual care group (75.3 versus 60.2%; p = 0.04). There was no effect of the intervention on serum NfL [intervention: baseline NfL (pg/mL) 25.76, change from baseline 0.87; usual care: baseline 27.09, change from baseline -1.16, p = 0.09].CONCLUSION: The findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. Further studies are needed using other types and durations of exercise and other measures of neurodegeneration.CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, identifier NCT01681602.
AB - INTRODUCTION: Aerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.OBJECTIVE: To investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer's disease (AD).METHODS: This is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer's disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention.RESULTS: A total of 136 participants were included in the analysis. Groups were comparable at baseline except for APOEε4 carriership which was higher in the usual care group (75.3 versus 60.2%; p = 0.04). There was no effect of the intervention on serum NfL [intervention: baseline NfL (pg/mL) 25.76, change from baseline 0.87; usual care: baseline 27.09, change from baseline -1.16, p = 0.09].CONCLUSION: The findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. Further studies are needed using other types and durations of exercise and other measures of neurodegeneration.CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, identifier NCT01681602.
KW - Alzheimer’s disease
KW - dementia
KW - exercise
KW - intervention
KW - neurodegeneration
KW - neurofilament light
U2 - 10.3389/fnins.2023.1108191
DO - 10.3389/fnins.2023.1108191
M3 - Journal article
C2 - 36761410
SN - 1662-4548
VL - 17
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 1108191
ER -