An attempt to explain the bidirectional association between ischaemic heart disease, stroke and depression: a cohort and meta-analytic approach

Marie Kim Wium-Andersen, Ida Kim Wium-Andersen, Eva Irene Bosano Prescott, Kim Overvad, Martin Balslev Jørgensen, Merete Osler

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: Depression and cardiovascular diseases (CVDs) are common diseases and associated in a bidirectional manner.AimsTo examine whether a bidirectional association between CVD and depression could be explained by shared risk factors, misclassification of disease measures or non-response.

METHOD: A total of 10 population-based cohorts including 93 076 men and women (mean age 54.4 years, s.d. = 9.2) and an additional 10 510 men (mean age 51.2 years, s.d. = 0.3) were followed for subsequent depression, ischaemic heart disease (IHD) and stroke in the Danish National Patient Registry from health examinations between 1982 and 2015 and until end of follow-up in 2017-2018. Exposures were physicians' diagnoses of IHD, stroke, depression or self-reported chest pain, depression, use of antidepressant medication and the Major Depression Inventory at the time of study entry in the Metropolit study. Associations were analysed using Cox proportional hazard regression with disease as time-dependent variables.

RESULTS: IHD and stroke were associated with subsequent depression (hazard ratio (HR) for IHD: 1.79, 95% CI 1.43-2.23 and HR for stroke: 2.62, 95% CI 2.09-3.29) and the associations were present in both men and women. Adjustment for the shared risk factors socioeconomic status, lifestyle, body mass index, statin use and serum lipids did not change the risk estimates. Furthermore, depression was associated with higher risk of subsequent IHD (HR = 1.63, 95% CI 1.36-1.95) and stroke (HR = 1.94, 95% CI 1.63-2.30). The associations were also present when the analyses were based on self-reported disease measures or restricted to include non-responders.

CONCLUSIONS: The bidirectional association between CVD and depression was not explained by shared risk factors, misclassification or non-response.Declaration of interestNone.

Original languageEnglish
JournalThe British journal of psychiatry : the journal of mental science
Number of pages8
DOIs
Publication statusE-pub ahead of print - 10 Jun 2019

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Myocardial Ischemia
Stroke
Depression
Cardiovascular Diseases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Time and Motion Studies
Chest Pain
Social Class
Antidepressive Agents
Registries
Life Style
Body Mass Index
Physicians
Lipids
Equipment and Supplies
Health
Serum
Population

Cite this

@article{e6d0305cae2e408896fdcfc663d70891,
title = "An attempt to explain the bidirectional association between ischaemic heart disease, stroke and depression: a cohort and meta-analytic approach",
abstract = "BACKGROUND: Depression and cardiovascular diseases (CVDs) are common diseases and associated in a bidirectional manner.AimsTo examine whether a bidirectional association between CVD and depression could be explained by shared risk factors, misclassification of disease measures or non-response.METHOD: A total of 10 population-based cohorts including 93 076 men and women (mean age 54.4 years, s.d. = 9.2) and an additional 10 510 men (mean age 51.2 years, s.d. = 0.3) were followed for subsequent depression, ischaemic heart disease (IHD) and stroke in the Danish National Patient Registry from health examinations between 1982 and 2015 and until end of follow-up in 2017-2018. Exposures were physicians' diagnoses of IHD, stroke, depression or self-reported chest pain, depression, use of antidepressant medication and the Major Depression Inventory at the time of study entry in the Metropolit study. Associations were analysed using Cox proportional hazard regression with disease as time-dependent variables.RESULTS: IHD and stroke were associated with subsequent depression (hazard ratio (HR) for IHD: 1.79, 95{\%} CI 1.43-2.23 and HR for stroke: 2.62, 95{\%} CI 2.09-3.29) and the associations were present in both men and women. Adjustment for the shared risk factors socioeconomic status, lifestyle, body mass index, statin use and serum lipids did not change the risk estimates. Furthermore, depression was associated with higher risk of subsequent IHD (HR = 1.63, 95{\%} CI 1.36-1.95) and stroke (HR = 1.94, 95{\%} CI 1.63-2.30). The associations were also present when the analyses were based on self-reported disease measures or restricted to include non-responders.CONCLUSIONS: The bidirectional association between CVD and depression was not explained by shared risk factors, misclassification or non-response.Declaration of interestNone.",
author = "Wium-Andersen, {Marie Kim} and Wium-Andersen, {Ida Kim} and Prescott, {Eva Irene Bosano} and Kim Overvad and J{\o}rgensen, {Martin Balslev} and Merete Osler",
year = "2019",
month = "6",
day = "10",
doi = "10.1192/bjp.2019.130",
language = "English",
journal = "The British journal of psychiatry : the journal of mental science",
issn = "1472-1465",
publisher = "Royal College of Psychiatrists",

}

An attempt to explain the bidirectional association between ischaemic heart disease, stroke and depression : a cohort and meta-analytic approach. / Wium-Andersen, Marie Kim; Wium-Andersen, Ida Kim; Prescott, Eva Irene Bosano; Overvad, Kim; Jørgensen, Martin Balslev; Osler, Merete.

In: The British journal of psychiatry : the journal of mental science, 10.06.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - An attempt to explain the bidirectional association between ischaemic heart disease, stroke and depression

T2 - a cohort and meta-analytic approach

AU - Wium-Andersen, Marie Kim

AU - Wium-Andersen, Ida Kim

AU - Prescott, Eva Irene Bosano

AU - Overvad, Kim

AU - Jørgensen, Martin Balslev

AU - Osler, Merete

PY - 2019/6/10

Y1 - 2019/6/10

N2 - BACKGROUND: Depression and cardiovascular diseases (CVDs) are common diseases and associated in a bidirectional manner.AimsTo examine whether a bidirectional association between CVD and depression could be explained by shared risk factors, misclassification of disease measures or non-response.METHOD: A total of 10 population-based cohorts including 93 076 men and women (mean age 54.4 years, s.d. = 9.2) and an additional 10 510 men (mean age 51.2 years, s.d. = 0.3) were followed for subsequent depression, ischaemic heart disease (IHD) and stroke in the Danish National Patient Registry from health examinations between 1982 and 2015 and until end of follow-up in 2017-2018. Exposures were physicians' diagnoses of IHD, stroke, depression or self-reported chest pain, depression, use of antidepressant medication and the Major Depression Inventory at the time of study entry in the Metropolit study. Associations were analysed using Cox proportional hazard regression with disease as time-dependent variables.RESULTS: IHD and stroke were associated with subsequent depression (hazard ratio (HR) for IHD: 1.79, 95% CI 1.43-2.23 and HR for stroke: 2.62, 95% CI 2.09-3.29) and the associations were present in both men and women. Adjustment for the shared risk factors socioeconomic status, lifestyle, body mass index, statin use and serum lipids did not change the risk estimates. Furthermore, depression was associated with higher risk of subsequent IHD (HR = 1.63, 95% CI 1.36-1.95) and stroke (HR = 1.94, 95% CI 1.63-2.30). The associations were also present when the analyses were based on self-reported disease measures or restricted to include non-responders.CONCLUSIONS: The bidirectional association between CVD and depression was not explained by shared risk factors, misclassification or non-response.Declaration of interestNone.

AB - BACKGROUND: Depression and cardiovascular diseases (CVDs) are common diseases and associated in a bidirectional manner.AimsTo examine whether a bidirectional association between CVD and depression could be explained by shared risk factors, misclassification of disease measures or non-response.METHOD: A total of 10 population-based cohorts including 93 076 men and women (mean age 54.4 years, s.d. = 9.2) and an additional 10 510 men (mean age 51.2 years, s.d. = 0.3) were followed for subsequent depression, ischaemic heart disease (IHD) and stroke in the Danish National Patient Registry from health examinations between 1982 and 2015 and until end of follow-up in 2017-2018. Exposures were physicians' diagnoses of IHD, stroke, depression or self-reported chest pain, depression, use of antidepressant medication and the Major Depression Inventory at the time of study entry in the Metropolit study. Associations were analysed using Cox proportional hazard regression with disease as time-dependent variables.RESULTS: IHD and stroke were associated with subsequent depression (hazard ratio (HR) for IHD: 1.79, 95% CI 1.43-2.23 and HR for stroke: 2.62, 95% CI 2.09-3.29) and the associations were present in both men and women. Adjustment for the shared risk factors socioeconomic status, lifestyle, body mass index, statin use and serum lipids did not change the risk estimates. Furthermore, depression was associated with higher risk of subsequent IHD (HR = 1.63, 95% CI 1.36-1.95) and stroke (HR = 1.94, 95% CI 1.63-2.30). The associations were also present when the analyses were based on self-reported disease measures or restricted to include non-responders.CONCLUSIONS: The bidirectional association between CVD and depression was not explained by shared risk factors, misclassification or non-response.Declaration of interestNone.

U2 - 10.1192/bjp.2019.130

DO - 10.1192/bjp.2019.130

M3 - Journal article

C2 - 31179963

JO - The British journal of psychiatry : the journal of mental science

JF - The British journal of psychiatry : the journal of mental science

SN - 1472-1465

ER -