An open-loop, physiological model based decision support system can reduce pressure support while acting to preserve respiratory muscle function

Savino Spadaro, Dan Stieper Karbing, Francesca Dalla Corte, Tommaso Mauri, Federico Moro, Antonio Gioia, Carlo Alberto Volta, Stephen Edward Rees

Research output: Contribution to journalJournal article

3 Citations (Scopus)


Purpose: To assess whether a clinical decision support system (CDSS) suggests PS and FIO 2 maintaining appropriate breathing effort, and minimizing FIO 2. Materials: Prospective, cross-over study in PS ventilated ICU patients. Over support (150% baseline) and under support (50% baseline) were applied by changing PS (15 patients) or PEEP (8 patients). CDSS advice was followed. Tension time index of inspiratory muscles (TTies), respiratory and metabolic variables were measured. Results: PS over support (median 8.0 to 12.0 cmH 2O) reduced respiratory muscle activity (TTies 0.090 ± 0.028 to 0.049 ± 0.030; p <.01), and tended to increase tidal volume (VT: 8.6 ± 3.0 to 10.1 ± 2.9 ml/kg; p =.08). CDSS advice reduced PS (6.0 cmH 2O, p =.005), increased TTies (0.076 ± 0.038, p <.01), and tended to reduce VT (8.9 ± 2.4 ml/kg, p =.08). PS under support (12.0 to 4.0 cmH 2O) slightly increased respiratory muscle activity, (TTies to 0.120 ± 0.044; p =.007) with no significant CDSS advice. CDSS advice reduced FIO 2 by 12–14% (p =.005), resulting in median SpO 2 = 96% (p <.02). PEEP changes did not result in changes in physiological variables, or CDSS advice. Conclusion: The CDSS advised on low values of PS often not prohibiting extubation, while acting to preserve respiratory muscle function and preventing passive lung inflation. CDSS advice minimized FIO 2 maintaining SpO 2 at safe and beneficial values.

Original languageEnglish
JournalJournal of Critical Care
Pages (from-to)407-413
Number of pages7
Publication statusPublished - 2018



  • Clinical decision support
  • Esophageal pressure
  • Mechanical ventilation
  • Physiological models
  • Pressure support

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