Main Category: B (basic research)

Topic: Pharmacological therapies

Background and aims: Halophyte plants acclimated for growth in saline soils such as along coastal areas and marshes. Within the halophytes, Salicornia species have been for long time used as both food and medicine due to their high levels of bioactive compounds with supposed anti-inflammatory and antioxidative effects. However, the properties of Salicornia bioactive extracts on pain and itch remain still to be investigated.

Methods: ​In this study, 30 healthy volunteers were randomized to treatments with 10% Salicornia-based cream or placebo cream for 24 or 48 hours. On day 0, and 24 or 48 hours post cream application quantitative sensory tests were assessed. The test included cold/heat detection and pain thresholds, mechanical pain thresholds and sensitivity, trans-epidermal water loss, histamine and cowhage evoked itch, and micro-vascular reactivity (neurogenic inflammation), to evaluate the analgesic, anti-pruritogenic and vasomotor effects of Salicornia cream.

Results: Skin permeability was reduced in the Salicornia treated area for 48-hours compared to 24-hours application (p-value <0.05). After 48-hours of application a decrease in mechanical evoked itch (hyperkinesis) (p-value <0.05) and increased warm detection and heat pain thresholds (p-value <0.05) were found compared to 24 hours treatment. Histamine induced neurogenic inflammation showed a significant reduction in the 48-hour creams treated areas compared to 24-hour (p-value <0.05).

Conclusions: The results of this study indicate an overall inhibitory effect of Salicornia cream on hyperkinesis (mechanical evoked itch), analgesic effect on warmth and heat sensations, and modulation of the skin barrier architecture. Further studies are needed for the assessment of the long-term effects.
Original languageEnglish
Publication date2022
Publication statusPublished - 2022
EventEFIC2022 European Pain Federation - dublin, Ireland
Duration: 27 Apr 202230 Apr 2022


ConferenceEFIC2022 European Pain Federation


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