TY - JOUR
T1 - Anaphylactic shock and cardiac arrest caused by thiamine infusion
AU - Juel, Jacob
AU - Pareek, Manan
AU - Langfrits, Christian Sigvald
AU - Jensen, Svend Eggert
PY - 2013/7/12
Y1 - 2013/7/12
N2 - Parenteral thiamine has a very high safety profile. The most common adverse effect is local irritation; however, anaphylactic or anaphylactoid reactions may occur, mostly related to intravenous administration. We describe a 44-year-old man, a chronic alcoholic, who was admitted with alcohol intoxication and developed cardiac arrest due to anaphylactic shock following intravenous thiamine infusion. The patient was successfully resuscitated after 15 min and repeated epinephrine administrations. He was discharged in good health after 14 days. This case report emphasises both the importance of recognising the symptoms of anaphylaxis and the fact that facilities for treating anaphylaxis and cardiopulmonary resuscitation should be available when thiamine or for that matter, any drug is given in-hospital.
AB - Parenteral thiamine has a very high safety profile. The most common adverse effect is local irritation; however, anaphylactic or anaphylactoid reactions may occur, mostly related to intravenous administration. We describe a 44-year-old man, a chronic alcoholic, who was admitted with alcohol intoxication and developed cardiac arrest due to anaphylactic shock following intravenous thiamine infusion. The patient was successfully resuscitated after 15 min and repeated epinephrine administrations. He was discharged in good health after 14 days. This case report emphasises both the importance of recognising the symptoms of anaphylaxis and the fact that facilities for treating anaphylaxis and cardiopulmonary resuscitation should be available when thiamine or for that matter, any drug is given in-hospital.
U2 - 10.1136/bcr-2013-009648
DO - 10.1136/bcr-2013-009648
M3 - Journal article
C2 - 23853017
SN - 1757-790X
VL - 2013
JO - B M J Case Reports
JF - B M J Case Reports
IS - 12 Jul
ER -