Animal models of pancreatitis: Can it be translated to human pain study?

Jingbo Zhao, Donghua Liao, Thomas Dahl Nissen

Research output: Contribution to journalJournal articleResearchpeer-review

21 Citations (Scopus)


Chronic pancreatitis affects many individuals around the world, and the study of the underlying mechanisms leading to better treatment possibilities are important tasks. Therefore, animal models are needed to illustrate the basic study of pancreatitis. Recently, animal models of acute and chronic pancreatitis have been thoroughly reviewed, but few reviews address the important aspect on the translation of animal studies to human studies. It is well known that pancreatitis is associated with epigastric pain, but the understanding regarding to mechanisms and appropriate treatment of this pain is still unclear. Using animal models to study pancreatitis associated visceral pain is difficult, however, these types of models are a unique way to reveal the mechanisms behind pancreatitis associated visceral pain. In this review, the animal models of acute, chronic and un-common pancreatitis are briefly outlined and animal models related to pancreatitis associated visceral pain are also addressed.
Original languageEnglish
JournalWorld Journal of Gastroenterology
Issue number42
Pages (from-to)7222-30
Number of pages9
Publication statusPublished - 14 Nov 2013


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