Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

Petra H Lahmann; Anne E Cust; Christine M Friedenreich; Mandy Schulz; Annekatrin Lukanova; Rudolf Kaaks; Eva Lundin; Anne Tjønneland; Jytte Halkjær; Marianne Tang Severinsen; Kim Overvad; Agnès Fournier; Nathalie Chabbert-Buffet; Françoise Clavel-Chapelon; Laure Dossus; Tobias Pischon; Heiner Boeing; Antonia Trichopoulou; Pagona Lagiou; Androniki Naska; Domenico Palli; Sara Grioni; Amalia Mattiello; Rosario Tumino; Carlotta Sacerdote; María-Luisa Redondo; Paula Jakszyn; María-José Sánchez; María-José Tormo; Eva Ardanaz; Larraitz Arriola; Jonas Manjer; Karin Jirström; H Bas Bueno-de-Mesquita; Anne M May; Petra H M Peeters; N Charlotte Onland-Moret; Sheila Bingham; Kay-Tee Khaw; Naomi E Allen; Elizabeth Spencer; Sabina Rinaldi; Nadia Slimani; Véronique Chajes; Dominique Michaud; Teresa Norat; Elio Riboli

doi:10.1002/ijc.24952

Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

Petra H Lahmann, Anne E Cust, Christine M Friedenreich, Mandy Schulz, Annekatrin Lukanova, Rudolf Kaaks, Eva Lundin, Anne Tjønneland, Jytte Halkjær, Marianne Tang Severinsen, Kim Overvad, Agnès Fournier, Nathalie Chabbert-Buffet, Françoise Clavel-Chapelon, Laure Dossus, Tobias Pischon, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Androniki NaskaDomenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, María-Luisa Redondo, Paula Jakszyn, María-José Sánchez, María-José Tormo, Eva Ardanaz, Larraitz Arriola, Jonas Manjer, Karin Jirström, H Bas Bueno-de-Mesquita, Anne M May, Petra H M Peeters, N Charlotte Onland-Moret, Sheila Bingham, Kay-Tee Khaw, Naomi E Allen, Elizabeth Spencer, Sabina Rinaldi, Nadia Slimani, Véronique Chajes, Dominique Michaud, Teresa Norat, Elio Riboli

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >/= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.

Original language	English
Journal	International Journal of Cancer
Volume	126
Pages (from-to)	2404-2415
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.24952
Publication status	Published - 2010
Externally published	Yes

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Lahmann, P. H., Cust, A. E., Friedenreich, C. M., Schulz, M., Lukanova, A., Kaaks, R., Lundin, E., Tjønneland, A., Halkjær, J., Severinsen, M. T., Overvad, K., Fournier, A., Chabbert-Buffet, N., Clavel-Chapelon, F., Dossus, L., Pischon, T., Boeing, H., Trichopoulou, A., Lagiou, P., ... Riboli, E. (2010). Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 126, 2404-2415. https://doi.org/10.1002/ijc.24952

@article{334bcca427574df884860bd8b9b9d572,

title = "Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition",

abstract = "We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >/= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.",

author = "Lahmann, {Petra H} and Cust, {Anne E} and Friedenreich, {Christine M} and Mandy Schulz and Annekatrin Lukanova and Rudolf Kaaks and Eva Lundin and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Severinsen, {Marianne Tang} and Kim Overvad and Agn{\`e}s Fournier and Nathalie Chabbert-Buffet and Fran{\c c}oise Clavel-Chapelon and Laure Dossus and Tobias Pischon and Heiner Boeing and Antonia Trichopoulou and Pagona Lagiou and Androniki Naska and Domenico Palli and Sara Grioni and Amalia Mattiello and Rosario Tumino and Carlotta Sacerdote and Mar{\'i}a-Luisa Redondo and Paula Jakszyn and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Mar{\'i}a-Jos{\'e} Tormo and Eva Ardanaz and Larraitz Arriola and Jonas Manjer and Karin Jirstr{\"o}m and Bueno-de-Mesquita, {H Bas} and May, {Anne M} and Peeters, {Petra H M} and Onland-Moret, {N Charlotte} and Sheila Bingham and Kay-Tee Khaw and Allen, {Naomi E} and Elizabeth Spencer and Sabina Rinaldi and Nadia Slimani and V{\'e}ronique Chajes and Dominique Michaud and Teresa Norat and Elio Riboli",

year = "2010",

doi = "10.1002/ijc.24952",

language = "English",

volume = "126",

pages = "2404--2415",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley",

}

Lahmann, PH, Cust, AE, Friedenreich, CM, Schulz, M, Lukanova, A, Kaaks, R, Lundin, E, Tjønneland, A, Halkjær, J, Severinsen, MT, Overvad, K, Fournier, A, Chabbert-Buffet, N, Clavel-Chapelon, F, Dossus, L, Pischon, T, Boeing, H, Trichopoulou, A, Lagiou, P, Naska, A, Palli, D, Grioni, S, Mattiello, A, Tumino, R, Sacerdote, C, Redondo, M-L, Jakszyn, P, Sánchez, M-J, Tormo, M-J, Ardanaz, E, Arriola, L, Manjer, J, Jirström, K, Bueno-de-Mesquita, HB, May, AM, Peeters, PHM, Onland-Moret, NC, Bingham, S, Khaw, K-T, Allen, NE, Spencer, E, Rinaldi, S, Slimani, N, Chajes, V, Michaud, D, Norat, T & Riboli, E 2010, 'Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 126, pp. 2404-2415. https://doi.org/10.1002/ijc.24952

TY - JOUR

T1 - Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

AU - Lahmann, Petra H

AU - Cust, Anne E

AU - Friedenreich, Christine M

AU - Schulz, Mandy

AU - Lukanova, Annekatrin

AU - Kaaks, Rudolf

AU - Lundin, Eva

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Severinsen, Marianne Tang

AU - Overvad, Kim

AU - Fournier, Agnès

AU - Chabbert-Buffet, Nathalie

AU - Clavel-Chapelon, Françoise

AU - Dossus, Laure

AU - Pischon, Tobias

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Naska, Androniki

AU - Palli, Domenico

AU - Grioni, Sara

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Redondo, María-Luisa

AU - Jakszyn, Paula

AU - Sánchez, María-José

AU - Tormo, María-José

AU - Ardanaz, Eva

AU - Arriola, Larraitz

AU - Manjer, Jonas

AU - Jirström, Karin

AU - Bueno-de-Mesquita, H Bas

AU - May, Anne M

AU - Peeters, Petra H M

AU - Onland-Moret, N Charlotte

AU - Bingham, Sheila

AU - Khaw, Kay-Tee

AU - Allen, Naomi E

AU - Spencer, Elizabeth

AU - Rinaldi, Sabina

AU - Slimani, Nadia

AU - Chajes, Véronique

AU - Michaud, Dominique

AU - Norat, Teresa

AU - Riboli, Elio

PY - 2010

Y1 - 2010

N2 - We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >/= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.

AB - We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >/= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.

U2 - 10.1002/ijc.24952

DO - 10.1002/ijc.24952

M3 - Journal article

SN - 0020-7136

VL - 126

SP - 2404

EP - 2415

JO - International Journal of Cancer

JF - International Journal of Cancer

ER -

Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

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