Abstract
INTRODUCTION: Brain abscess is an uncommon and potentially life-threatening infection of the CNS that can be caused by a range of different pathogens including bacteria, fungi and parasites. A multidisciplinary approach is important and anti-infective treatment remains crucial. Here, we review anti-infective treatment of brain abscess. Areas covered: We used the terms '(Brain abscess[ti] AND (antibiotic* OR treatment)) NOT case report'), to conduct a search in the PubMed. Additional papers were identified by cross-reference checking and by browsing textbooks of infectious diseases and neurology.
COMMENTARY: Empiric treatment of bacterial brain abscess consists of cefotaxime and metronidazole with the addition of vancomycin if meticilline-resistant Staphylococcus aureus is suspected. For severely immuno-suppressed patients, e.g., transplant recipients, voriconazole and TMP-SMX or sulfadiazine should be added. Increased knowledge of the pharmacokinetic profile of anti-infective treatments may help to improve the treatment of brain abscess. Future studies should address efficacy and safety of continuous abscess drainage, mode of anti-infective administration (continuous vs. bolus), and anti-infective treatments in immuno-suppressed patients.
Original language | English |
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Journal | Expert Review of Anti-infective Therapy |
Volume | 16 |
Issue number | 7 |
Pages (from-to) | 565-578 |
Number of pages | 14 |
ISSN | 1478-7210 |
DOIs | |
Publication status | Published - 18 Jun 2018 |
Keywords
- Brain abscess
- anti-infective
- antibiotic
- antifungal
- antimicrobial
- review
- therapy
- treatment
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Anti-infective treatment of brain abscess
Brouwer, M. C. (Creator), Nielsen, H. (Creator), Bodilsen, J. (Creator) & Van De Beek, D. (Contributor), Taylor & Francis, 1 Jan 2018
DOI: 10.6084/m9.figshare.6743720.v1, https://doi.org/10.6084%2Fm9.figshare.6743720.v1
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