Abstract
Introduction. Efficacy and safety of vitamin K antagonists (VKAs) among atrial fibrillation (AF) patients are enhanced when the International Normalised Ratio (INR) is 2.0–3.0. Anticoagulation control among older patients is perceived to be lower and contributes to poorer initiation and uptake. Objective. To examine the quality of INR control, adverse clinical outcomes, and factors associated with bleeding in older AF patients (≥80 years). Methods. Anticoagulation control assessed by time in therapeutic range (TTR) (Rosendaal method) and percentage INRs in range (PINRR). Among the 205 patients aged ≥80 years, 58.5% were female, with mean (SD) CHA2DS2-VASc 4.4 (1.3) and HAS-BLED 1.8 (0.8) scores. Results. Mean (SD) TTR and PINRR were similar for those aged ≥80 vs.
Original language | English |
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Article number | 5951262 |
Journal | International Journal of Clinical Practice |
Volume | 2022 |
Pages (from-to) | 5951262 |
Number of pages | 8 |
ISSN | 1368-5031 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Copyright © 2022 Hanis Zulkifly et al.Keywords
- Aged
- Aged, 80 and over
- Anticoagulants/adverse effects
- Atrial Fibrillation/complications
- Female
- Fibrinolytic Agents/therapeutic use
- Hemorrhage/chemically induced
- Humans
- International Normalized Ratio/adverse effects
- Male
- Stroke/complications
- Vitamin K