TY - JOUR
T1 - Arterial and transcutaneous variability and agreement between multiple successive measurements of carbon dioxide in patients with chronic obstructive lung disease
AU - Thomsen, Lars Pilegaard
AU - Faaborg, Thea Heide
AU - Rees, Stephen Edward
AU - Weinreich, Ulla Møller
PY - 2020/9
Y1 - 2020/9
N2 - PURPOSE: This study evaluates agreement between carbon dioxide measured arterial (PaCO2) and transcutaneous (PtcCO2) over time, by repeated successive measures, taking into consideration the inherent variability of arterial measurements.METHODS AND RESULTS: 11 patients receiving LTOT, with severe to very severe COPD in a stable phase were studied. Repeated arterial blood samples were drawn and PtcCO2 measured simultaneously at the ear lobe. Bland-Altman analysis was used to evaluate 95 % limits of agreement (LoA). 194 paired samples were analysed. Following correction for bias, the difference between PaCO2 and PtCO2 during dynamic conditions was 0.02 kPa and LoA 0.94 to -0.90 kPa while 29 % of PtCO2 measurements were outside the range of variability for arterial measurements.CONCLUSION: PtcCO2 corrected for intra-patient bias provide reasonable description of PaCO2 values within but not outside steady state conditions. Our results suggest that PtcCO2 is a valuable method for monitoring in chronic rather than acute conditions when bias can be removed.
AB - PURPOSE: This study evaluates agreement between carbon dioxide measured arterial (PaCO2) and transcutaneous (PtcCO2) over time, by repeated successive measures, taking into consideration the inherent variability of arterial measurements.METHODS AND RESULTS: 11 patients receiving LTOT, with severe to very severe COPD in a stable phase were studied. Repeated arterial blood samples were drawn and PtcCO2 measured simultaneously at the ear lobe. Bland-Altman analysis was used to evaluate 95 % limits of agreement (LoA). 194 paired samples were analysed. Following correction for bias, the difference between PaCO2 and PtCO2 during dynamic conditions was 0.02 kPa and LoA 0.94 to -0.90 kPa while 29 % of PtCO2 measurements were outside the range of variability for arterial measurements.CONCLUSION: PtcCO2 corrected for intra-patient bias provide reasonable description of PaCO2 values within but not outside steady state conditions. Our results suggest that PtcCO2 is a valuable method for monitoring in chronic rather than acute conditions when bias can be removed.
KW - Arterial blood gas measurement
KW - Carbon dioxide
KW - Chronic obstructive pulmonary disease
KW - Long-term oxygen therapy
KW - Physiologic monitoring
KW - Transcutaneous blood gas measurement
UR - http://www.scopus.com/inward/record.url?scp=85087712765&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2020.103486
DO - 10.1016/j.resp.2020.103486
M3 - Journal article
C2 - 32615271
SN - 1569-9048
VL - 280
JO - Respiratory Physiology & Neurobiology
JF - Respiratory Physiology & Neurobiology
M1 - 103486
ER -