Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)

Abstract

Introduction: Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. Methods: Small sensory fibers were selectively blocked by 120-minute topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength–duration relation and threshold electrotonus. Results: The excitability assessed by the strength–duration relation and threshold electrotonus was significantly modulated for the small afferents (P < 0.05, Wilcoxon's test) but not the large afferents. Discussion: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers, suggesting the usefulness of the technique as a diagnostic method for assessing impairment of small fibers, as seen in many types of polyneuropathies. Muscle Nerve, 2019.

Original languageEnglish
JournalMuscle & Nerve
Volume60
Issue number4
Pages (from-to)367-375
Number of pages9
ISSN0148-639X
DOIs
Publication statusPublished - Oct 2019

Fingerprint

Nerve Fibers
Prilocaine
Lidocaine
Skin
Electrodes
Polyneuropathies
Muscles
Membranes

Bibliographical note

© 2019 Wiley Periodicals, Inc.

Keywords

  • cutaneous analgesia
  • nerve fiber excitability
  • perception thresholds
  • pin electrode
  • quantitative sensory testing
  • small fiber neuropathy
  • threshold tracking

Cite this

@article{7031433c18ca4248b02230cef72567e3,
title = "Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique",
abstract = "Introduction: Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. Methods: Small sensory fibers were selectively blocked by 120-minute topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength–duration relation and threshold electrotonus. Results: The excitability assessed by the strength–duration relation and threshold electrotonus was significantly modulated for the small afferents (P < 0.05, Wilcoxon's test) but not the large afferents. Discussion: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers, suggesting the usefulness of the technique as a diagnostic method for assessing impairment of small fibers, as seen in many types of polyneuropathies. Muscle Nerve, 2019.",
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author = "Hoberg, {Tatiana Nielson} and Steffen Frahm and Kristian Hennings and Lars Arendt-Nielsen and M{\o}rch, {Carsten Dahl}",
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Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique. / Hoberg, Tatiana Nielson; Frahm, Steffen; Hennings, Kristian; Arendt-Nielsen, Lars; Mørch, Carsten Dahl.

In: Muscle & Nerve, Vol. 60, No. 4, 10.2019, p. 367-375.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique

AU - Hoberg, Tatiana Nielson

AU - Frahm, Steffen

AU - Hennings, Kristian

AU - Arendt-Nielsen, Lars

AU - Mørch, Carsten Dahl

N1 - © 2019 Wiley Periodicals, Inc.

PY - 2019/10

Y1 - 2019/10

N2 - Introduction: Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. Methods: Small sensory fibers were selectively blocked by 120-minute topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength–duration relation and threshold electrotonus. Results: The excitability assessed by the strength–duration relation and threshold electrotonus was significantly modulated for the small afferents (P < 0.05, Wilcoxon's test) but not the large afferents. Discussion: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers, suggesting the usefulness of the technique as a diagnostic method for assessing impairment of small fibers, as seen in many types of polyneuropathies. Muscle Nerve, 2019.

AB - Introduction: Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. Methods: Small sensory fibers were selectively blocked by 120-minute topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength–duration relation and threshold electrotonus. Results: The excitability assessed by the strength–duration relation and threshold electrotonus was significantly modulated for the small afferents (P < 0.05, Wilcoxon's test) but not the large afferents. Discussion: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers, suggesting the usefulness of the technique as a diagnostic method for assessing impairment of small fibers, as seen in many types of polyneuropathies. Muscle Nerve, 2019.

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