Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique

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Abstract

INTRODUCTION: Topical application of lidocaine and prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique.

METHODS: Small sensory fibers were selectively blocked by 120min topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength-duration relation and threshold-electrotonus.

RESULTS: The excitability assessed by the strength-duration relation and threshold-electrotonus was significantly modulated for the small (p<0.05, Wilcoxon), but not large afferents.

DISCUSSION: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers suggesting the technique as a diagnostic method for assessing impairment of small fibers as seen in many types of polyneuropathies. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalMuscle & Nerve
ISSN0148-639X
DOIs
Publication statusE-pub ahead of print - 20 May 2019

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Nerve Fibers
Prilocaine
Lidocaine
Skin
Electrodes
Polyneuropathies
Membranes

Cite this

@article{7031433c18ca4248b02230cef72567e3,
title = "Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique",
abstract = "INTRODUCTION: Topical application of lidocaine and prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique.METHODS: Small sensory fibers were selectively blocked by 120min topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength-duration relation and threshold-electrotonus.RESULTS: The excitability assessed by the strength-duration relation and threshold-electrotonus was significantly modulated for the small (p<0.05, Wilcoxon), but not large afferents.DISCUSSION: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers suggesting the technique as a diagnostic method for assessing impairment of small fibers as seen in many types of polyneuropathies. This article is protected by copyright. All rights reserved.",
author = "Hoberg, {Tatiana Nielson} and Steffen Frahm and Kristian Hennings and Lars Arendt-Nielsen and M{\o}rch, {Carsten Dahl}",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "5",
day = "20",
doi = "10.1002/mus.26520",
language = "English",
journal = "Muscle & Nerve",
issn = "0148-639X",
publisher = "Wiley",

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TY - JOUR

T1 - Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique

AU - Hoberg, Tatiana Nielson

AU - Frahm, Steffen

AU - Hennings, Kristian

AU - Arendt-Nielsen, Lars

AU - Mørch, Carsten Dahl

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/5/20

Y1 - 2019/5/20

N2 - INTRODUCTION: Topical application of lidocaine and prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique.METHODS: Small sensory fibers were selectively blocked by 120min topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength-duration relation and threshold-electrotonus.RESULTS: The excitability assessed by the strength-duration relation and threshold-electrotonus was significantly modulated for the small (p<0.05, Wilcoxon), but not large afferents.DISCUSSION: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers suggesting the technique as a diagnostic method for assessing impairment of small fibers as seen in many types of polyneuropathies. This article is protected by copyright. All rights reserved.

AB - INTRODUCTION: Topical application of lidocaine and prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique.METHODS: Small sensory fibers were selectively blocked by 120min topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength-duration relation and threshold-electrotonus.RESULTS: The excitability assessed by the strength-duration relation and threshold-electrotonus was significantly modulated for the small (p<0.05, Wilcoxon), but not large afferents.DISCUSSION: This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers suggesting the technique as a diagnostic method for assessing impairment of small fibers as seen in many types of polyneuropathies. This article is protected by copyright. All rights reserved.

U2 - 10.1002/mus.26520

DO - 10.1002/mus.26520

M3 - Journal article

JO - Muscle & Nerve

JF - Muscle & Nerve

SN - 0148-639X

ER -