Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis

Søren S Olesen; Louise Kuhlmann; Srdan Novovic; Camilla Nøjgaard; Evangelos Kalaitzakis; Nanna M Jensen; Trond Engjom; Georg Dimcevski; Anne Waage; Stephan L Haas; Miroslav Vujasinovic; Romualdas Riauka; Aldis Pukitis; Imanta Ozola-Zālīte; Alexey Okhlobystin; Mikael Parhiala; Johanna Laukkarinen; Asbjørn M Drewes; Scandinavian Baltic Pancreatic Club

doi:10.1111/jgh.14783

Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis

Søren S Olesen, Louise Kuhlmann, Srdan Novovic, Camilla Nøjgaard, Evangelos Kalaitzakis, Nanna M Jensen, Trond Engjom, Georg Dimcevski, Anne Waage, Stephan L Haas, Miroslav Vujasinovic, Romualdas Riauka, Aldis Pukitis, Imanta Ozola-Zālīte, Alexey Okhlobystin, Mikael Parhiala, Johanna Laukkarinen, Asbjørn M Drewes, Scandinavian Baltic Pancreatic Club

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Abstract

BACKGROUND AND AIM: Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number of patient and disease characteristics. However, the complex interrelations of these parameters are incompletely understood, and pain treatment remains unsatisfactory in a large proportion of patients. The aim of this study is to investigate multiple pain risk factors in a large population of CP patients, with a special emphasis on patients' patterns of smoking and alcohol use.

METHODS: This was a multicenter, cross-sectional study including 1384 patients with CP. Patient demographics and disease characteristics, as well as current patterns of smoking and alcohol use, were compared for patients with pain (n = 801) versus without pain (n = 583). Multivariate logistic regression models were performed to assess the variables associated with the presence and type of pain (constant vs intermittent pain).

RESULTS: The mean age of participants was 52.1 ± 14.6 years, and 914 (66%) were men. Active smoking (odds ratio 1.6 [95% confidence interval 1.1-2.2], P = 0.005) and alcohol consumption (odds ratio 1.8 [95% confidence interval 1.1-3.0], P = 0.03) were independently associated with the presence of pain. In addition, patients' age at diagnosis, pancreatic duct pathology, and the presence of pseudocysts, duodenal stenosis, and exocrine pancreatic insufficiency were confirmed as pain risk factors (all P ≤ 0.01). Constant pain, as opposed to intermittent pain, was more frequently reported by smokers (P = 0.03), while alcohol consumption was associated with intermittent pain (P = 0.006).

CONCLUSION: Multiple patient and disease characteristics, including patterns of smoking and alcohol consumption, associate with the presence and type of pain in patients with CP.

Original language	English
Journal	Journal of Gastroenterology and Hepatology
Volume	35
Issue number	2
Pages (from-to)	326-333
Number of pages	8
ISSN	0815-9319
DOIs	https://doi.org/10.1111/jgh.14783
Publication status	Published - Feb 2020

Keywords

chronic pancreatitis
pain
risk factors
smoking

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Olesen, S. S., Kuhlmann, L., Novovic, S., Nøjgaard, C., Kalaitzakis, E., Jensen, N. M., Engjom, T., Dimcevski, G., Waage, A., Haas, S. L., Vujasinovic, M., Riauka, R., Pukitis, A., Ozola-Zālīte, I., Okhlobystin, A., Parhiala, M., Laukkarinen, J., Drewes, A. M., & Scandinavian Baltic Pancreatic Club (2020). Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis. Journal of Gastroenterology and Hepatology, 35(2), 326-333. Advance online publication. https://doi.org/10.1111/jgh.14783

@article{4ca8c83ac19d48bbb77180b445d84583,

title = "Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis",

abstract = "BACKGROUND AND AIM: Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number of patient and disease characteristics. However, the complex interrelations of these parameters are incompletely understood, and pain treatment remains unsatisfactory in a large proportion of patients. The aim of this study is to investigate multiple pain risk factors in a large population of CP patients, with a special emphasis on patients' patterns of smoking and alcohol use.METHODS: This was a multicenter, cross-sectional study including 1384 patients with CP. Patient demographics and disease characteristics, as well as current patterns of smoking and alcohol use, were compared for patients with pain (n = 801) versus without pain (n = 583). Multivariate logistic regression models were performed to assess the variables associated with the presence and type of pain (constant vs intermittent pain).RESULTS: The mean age of participants was 52.1 ± 14.6 years, and 914 (66%) were men. Active smoking (odds ratio 1.6 [95% confidence interval 1.1-2.2], P = 0.005) and alcohol consumption (odds ratio 1.8 [95% confidence interval 1.1-3.0], P = 0.03) were independently associated with the presence of pain. In addition, patients' age at diagnosis, pancreatic duct pathology, and the presence of pseudocysts, duodenal stenosis, and exocrine pancreatic insufficiency were confirmed as pain risk factors (all P ≤ 0.01). Constant pain, as opposed to intermittent pain, was more frequently reported by smokers (P = 0.03), while alcohol consumption was associated with intermittent pain (P = 0.006).CONCLUSION: Multiple patient and disease characteristics, including patterns of smoking and alcohol consumption, associate with the presence and type of pain in patients with CP.",

keywords = "chronic pancreatitis, pain, risk factors, smoking",

author = "Olesen, {S{\o}ren S} and Louise Kuhlmann and Srdan Novovic and Camilla N{\o}jgaard and Evangelos Kalaitzakis and Jensen, {Nanna M} and Trond Engjom and Georg Dimcevski and Anne Waage and Haas, {Stephan L} and Miroslav Vujasinovic and Romualdas Riauka and Aldis Pukitis and Imanta Ozola-Zālīte and Alexey Okhlobystin and Mikael Parhiala and Johanna Laukkarinen and Drewes, {Asbj{\o}rn M} and {Scandinavian Baltic Pancreatic Club}",

year = "2020",

month = feb,

doi = "10.1111/jgh.14783",

language = "English",

volume = "35",

pages = "326--333",

journal = "Journal of Gastroenterology and Hepatology",

issn = "0815-9319",

publisher = "Wiley-Blackwell",

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}

Olesen, SS , Kuhlmann, L, Novovic, S, Nøjgaard, C, Kalaitzakis, E, Jensen, NM, Engjom, T, Dimcevski, G, Waage, A, Haas, SL, Vujasinovic, M, Riauka, R, Pukitis, A, Ozola-Zālīte, I, Okhlobystin, A, Parhiala, M, Laukkarinen, J, Drewes, AM & Scandinavian Baltic Pancreatic Club 2020, 'Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis', Journal of Gastroenterology and Hepatology, vol. 35, no. 2, pp. 326-333. https://doi.org/10.1111/jgh.14783

TY - JOUR

T1 - Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis

AU - Olesen, Søren S

AU - Kuhlmann, Louise

AU - Novovic, Srdan

AU - Nøjgaard, Camilla

AU - Kalaitzakis, Evangelos

AU - Jensen, Nanna M

AU - Engjom, Trond

AU - Dimcevski, Georg

AU - Waage, Anne

AU - Haas, Stephan L

AU - Vujasinovic, Miroslav

AU - Riauka, Romualdas

AU - Pukitis, Aldis

AU - Ozola-Zālīte, Imanta

AU - Okhlobystin, Alexey

AU - Parhiala, Mikael

AU - Laukkarinen, Johanna

AU - Drewes, Asbjørn M

AU - Scandinavian Baltic Pancreatic Club

PY - 2020/2

Y1 - 2020/2

N2 - BACKGROUND AND AIM: Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number of patient and disease characteristics. However, the complex interrelations of these parameters are incompletely understood, and pain treatment remains unsatisfactory in a large proportion of patients. The aim of this study is to investigate multiple pain risk factors in a large population of CP patients, with a special emphasis on patients' patterns of smoking and alcohol use.METHODS: This was a multicenter, cross-sectional study including 1384 patients with CP. Patient demographics and disease characteristics, as well as current patterns of smoking and alcohol use, were compared for patients with pain (n = 801) versus without pain (n = 583). Multivariate logistic regression models were performed to assess the variables associated with the presence and type of pain (constant vs intermittent pain).RESULTS: The mean age of participants was 52.1 ± 14.6 years, and 914 (66%) were men. Active smoking (odds ratio 1.6 [95% confidence interval 1.1-2.2], P = 0.005) and alcohol consumption (odds ratio 1.8 [95% confidence interval 1.1-3.0], P = 0.03) were independently associated with the presence of pain. In addition, patients' age at diagnosis, pancreatic duct pathology, and the presence of pseudocysts, duodenal stenosis, and exocrine pancreatic insufficiency were confirmed as pain risk factors (all P ≤ 0.01). Constant pain, as opposed to intermittent pain, was more frequently reported by smokers (P = 0.03), while alcohol consumption was associated with intermittent pain (P = 0.006).CONCLUSION: Multiple patient and disease characteristics, including patterns of smoking and alcohol consumption, associate with the presence and type of pain in patients with CP.

AB - BACKGROUND AND AIM: Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number of patient and disease characteristics. However, the complex interrelations of these parameters are incompletely understood, and pain treatment remains unsatisfactory in a large proportion of patients. The aim of this study is to investigate multiple pain risk factors in a large population of CP patients, with a special emphasis on patients' patterns of smoking and alcohol use.METHODS: This was a multicenter, cross-sectional study including 1384 patients with CP. Patient demographics and disease characteristics, as well as current patterns of smoking and alcohol use, were compared for patients with pain (n = 801) versus without pain (n = 583). Multivariate logistic regression models were performed to assess the variables associated with the presence and type of pain (constant vs intermittent pain).RESULTS: The mean age of participants was 52.1 ± 14.6 years, and 914 (66%) were men. Active smoking (odds ratio 1.6 [95% confidence interval 1.1-2.2], P = 0.005) and alcohol consumption (odds ratio 1.8 [95% confidence interval 1.1-3.0], P = 0.03) were independently associated with the presence of pain. In addition, patients' age at diagnosis, pancreatic duct pathology, and the presence of pseudocysts, duodenal stenosis, and exocrine pancreatic insufficiency were confirmed as pain risk factors (all P ≤ 0.01). Constant pain, as opposed to intermittent pain, was more frequently reported by smokers (P = 0.03), while alcohol consumption was associated with intermittent pain (P = 0.006).CONCLUSION: Multiple patient and disease characteristics, including patterns of smoking and alcohol consumption, associate with the presence and type of pain in patients with CP.

KW - chronic pancreatitis

KW - pain

KW - risk factors

KW - smoking

UR - http://www.scopus.com/inward/record.url?scp=85070105389&partnerID=8YFLogxK

U2 - 10.1111/jgh.14783

DO - 10.1111/jgh.14783

M3 - Journal article

C2 - 31314128

SN - 0815-9319

VL - 35

SP - 326

EP - 333

JO - Journal of Gastroenterology and Hepatology

JF - Journal of Gastroenterology and Hepatology

IS - 2

ER -

Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis

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