Atrial fibrillation and stroke

Sylvia E. Choi; Dimitrios Sagris; Andrew Hill; Gregory Y. H. Lip; Azmil H. Abdul-Rahim

doi:10.1080/14779072.2023.2160319

Atrial fibrillation and stroke

Sylvia E. Choi, Dimitrios Sagris, Andrew Hill, Gregory Y. H. Lip, Azmil H. Abdul-Rahim^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

121 Downloads (Pure)

Abstract

INTRODUCTION: Stroke is one of the leading causes of mortality and morbidity globally. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic proportions. AF is associated with a five-fold increase in risk of stroke. Strokes caused by AF more often are fatal or result in severe disability. Even though the incidence of stroke has been significantly reduced by oral anticoagulation, AF is thought to account for a significant proportion of cryptogenic strokes where no etiology is identified.

AREAS COVERED: This article reviews the literature related to AF and stroke, pathophysiological insights, diagnosis of AF in stroke patients, and its management (Graphical Abstract).

EXPERT OPINION: The pathophysiology of thrombogenesis that links AF and stroke is not well understood and is an area of active research to identify new therapeutic targets to prevent AF and stroke. As the nature of AF and stroke is multifaceted, an integrated care approach to managing AF and stroke is increasingly essential.

Original language	English
Journal	Expert Review of Cardiovascular Therapy
Volume	21
Issue number	1
Pages (from-to)	35-56
Number of pages	22
ISSN	1477-9072
DOIs	https://doi.org/10.1080/14779072.2023.2160319
Publication status	Published - Jan 2023

Keywords

Anticoagulants/therapeutic use
Atrial Fibrillation/complications
Humans
Incidence
Ischemic Stroke
Risk Factors
Stroke/epidemiology
integrated care approach
atrial fibrillation
embolic stroke
cryptogenic stroke
oral anticoagulation
stroke prevention
rhythm control

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10.1080/14779072.2023.2160319Licence: CC BY-NC-ND 4.0

Choi et al. (2023). Atrial fibrillation and strokeFinal published version, 1.48 MBLicence: CC BY-NC-ND 4.0

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title = "Atrial fibrillation and stroke",

abstract = "INTRODUCTION: Stroke is one of the leading causes of mortality and morbidity globally. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic proportions. AF is associated with a five-fold increase in risk of stroke. Strokes caused by AF more often are fatal or result in severe disability. Even though the incidence of stroke has been significantly reduced by oral anticoagulation, AF is thought to account for a significant proportion of cryptogenic strokes where no etiology is identified.AREAS COVERED: This article reviews the literature related to AF and stroke, pathophysiological insights, diagnosis of AF in stroke patients, and its management (Graphical Abstract).EXPERT OPINION: The pathophysiology of thrombogenesis that links AF and stroke is not well understood and is an area of active research to identify new therapeutic targets to prevent AF and stroke. As the nature of AF and stroke is multifaceted, an integrated care approach to managing AF and stroke is increasingly essential.",

keywords = "Anticoagulants/therapeutic use, Atrial Fibrillation/complications, Humans, Incidence, Ischemic Stroke, Risk Factors, Stroke/epidemiology, integrated care approach, atrial fibrillation, embolic stroke, cryptogenic stroke, oral anticoagulation, stroke prevention, rhythm control",

author = "Choi, {Sylvia E.} and Dimitrios Sagris and Andrew Hill and Lip, {Gregory Y. H.} and Abdul-Rahim, {Azmil H.}",

year = "2023",

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doi = "10.1080/14779072.2023.2160319",

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AU - Choi, Sylvia E.

AU - Sagris, Dimitrios

AU - Hill, Andrew

AU - Lip, Gregory Y. H.

AU - Abdul-Rahim, Azmil H.

PY - 2023/1

Y1 - 2023/1

N2 - INTRODUCTION: Stroke is one of the leading causes of mortality and morbidity globally. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic proportions. AF is associated with a five-fold increase in risk of stroke. Strokes caused by AF more often are fatal or result in severe disability. Even though the incidence of stroke has been significantly reduced by oral anticoagulation, AF is thought to account for a significant proportion of cryptogenic strokes where no etiology is identified.AREAS COVERED: This article reviews the literature related to AF and stroke, pathophysiological insights, diagnosis of AF in stroke patients, and its management (Graphical Abstract).EXPERT OPINION: The pathophysiology of thrombogenesis that links AF and stroke is not well understood and is an area of active research to identify new therapeutic targets to prevent AF and stroke. As the nature of AF and stroke is multifaceted, an integrated care approach to managing AF and stroke is increasingly essential.

AB - INTRODUCTION: Stroke is one of the leading causes of mortality and morbidity globally. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic proportions. AF is associated with a five-fold increase in risk of stroke. Strokes caused by AF more often are fatal or result in severe disability. Even though the incidence of stroke has been significantly reduced by oral anticoagulation, AF is thought to account for a significant proportion of cryptogenic strokes where no etiology is identified.AREAS COVERED: This article reviews the literature related to AF and stroke, pathophysiological insights, diagnosis of AF in stroke patients, and its management (Graphical Abstract).EXPERT OPINION: The pathophysiology of thrombogenesis that links AF and stroke is not well understood and is an area of active research to identify new therapeutic targets to prevent AF and stroke. As the nature of AF and stroke is multifaceted, an integrated care approach to managing AF and stroke is increasingly essential.

KW - Anticoagulants/therapeutic use

KW - Atrial Fibrillation/complications

KW - Humans

KW - Incidence

KW - Ischemic Stroke

KW - Risk Factors

KW - Stroke/epidemiology

KW - integrated care approach

KW - atrial fibrillation

KW - embolic stroke

KW - cryptogenic stroke

KW - oral anticoagulation

KW - stroke prevention

KW - rhythm control

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DO - 10.1080/14779072.2023.2160319

M3 - Review article

C2 - 36537565

SN - 1477-9072

VL - 21

SP - 35

EP - 56

JO - Expert Review of Cardiovascular Therapy

JF - Expert Review of Cardiovascular Therapy

IS - 1

ER -

Atrial fibrillation and stroke

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