Behandlingsniveau og behandlingsstop ved benign lungesygdom

Translated title of the contribution: Combination therapy of thyroxine and triiodothyronine in hypothyroid patients

Anita Rath Sørensen, Elisabeth Brendstrup, Ingrid Louise Titlestad, Jens Ulrik Stæhr Jensen, Laura Hohwu Thomsen, Nassim Bazeghi Roberts, Pia Holland Gjørup, Saher Shaker, Svend Gundestrup, Torgny Rostrup Wilcke, Ulla Møller Weinreich, Kristoffer Marså

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

Translated title of the contributionCombination therapy of thyroxine and triiodothyronine in hypothyroid patients
Original languageDanish
Article numberV04180270
JournalUgeskrift for Laeger
Volume180
Pages (from-to)2-6
Number of pages5
ISSN0041-5782
Publication statusPublished - 2018

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