TY - JOUR
T1 - Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition
AU - van Duijnhoven, Fränzel J B
AU - Bueno-De-Mesquita, H Bas
AU - Calligaro, Miriam
AU - Jenab, Mazda
AU - Pischon, Tobias
AU - Jansen, Eugène H J M
AU - Frohlich, Jiri
AU - Ayyobi, Amir
AU - Overvad, Kim
AU - Toft-Petersen, Anne Pernille
AU - Tjønneland, Anne
AU - Hansen, Louise
AU - Boutron-Ruault, Marie-Christine
AU - Clavel-Chapelon, Françoise
AU - Cottet, Vanessa
AU - Palli, Domenico
AU - Tagliabue, Giovanna
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Kaaks, Rudolf
AU - Teucher, Birgit
AU - Boeing, Heiner
AU - Drogan, Dagmar
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Dilis, Vardis
AU - Peeters, Petra H M
AU - Siersema, Peter D
AU - Rodríguez, Laudina
AU - González, Carlos A
AU - Molina-Montes, Esther
AU - Dorronsoro, Miren
AU - Tormo, Maria-Jose
AU - Barricarte, Aurelio
AU - Palmqvist, Richard
AU - Hallmans, Göran
AU - Khaw, Kay-Tee
AU - Tsilidis, Kostas K
AU - Crowe, Francesca L
AU - Chajes, Veronique
AU - Fedirko, Veronika
AU - Rinaldi, Sabina
AU - Norat, Teresa
AU - Riboli, Elio
PY - 2011/8
Y1 - 2011/8
N2 - OBJECTIVE: To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC).DESIGN: Nested case-control study.SETTING: The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520,000 participants from 10 western European countries.PARTICIPANTS: 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status.MAIN OUTCOME MEASURES: Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy.RESULTS: After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer.CONCLUSIONS: These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.
AB - OBJECTIVE: To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC).DESIGN: Nested case-control study.SETTING: The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520,000 participants from 10 western European countries.PARTICIPANTS: 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status.MAIN OUTCOME MEASURES: Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy.RESULTS: After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer.CONCLUSIONS: These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.
KW - Aged
KW - Biomarkers, Tumor
KW - Body Mass Index
KW - Colorectal Neoplasms
KW - Colorimetry
KW - Europe
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Incidence
KW - Lipids
KW - Lipoproteins
KW - Male
KW - Middle Aged
KW - Nephelometry and Turbidimetry
KW - Nutrition Surveys
KW - Patient Education as Topic
KW - Prognosis
KW - Prospective Studies
KW - Risk Factors
KW - Surveys and Questionnaires
KW - Comparative Study
KW - Journal Article
KW - Multicenter Study
KW - Research Support, Non-U.S. Gov't
U2 - 10.1136/gut.2010.225011
DO - 10.1136/gut.2010.225011
M3 - Journal article
C2 - 21383385
SN - 0017-5749
VL - 60
SP - 1094
EP - 1102
JO - Gut
JF - Gut
IS - 8
ER -