Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients - a randomized controlled trial comparing continuous and short-term infusion

Mikkel Tøttrup, Kjeld Søballe, Bo M Bibby, Tore F Hardlei, Peter Hansen, Kurt Fuursted, Hanne Birke-Sørensen, Mats Bue

Research output: Contribution to journalJournal articleResearchpeer-review

4 Citations (Scopus)
Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number12
Pages (from-to)779-788
Number of pages10
ISSN0903-4641
DOIs
Publication statusPublished - Dec 2019

Keywords

  • bone concentrations
  • cefuroxime
  • continuous infusion
  • microdialysis
  • population pharmacokinetics
  • Bone and Bones/metabolism
  • Anti-Bacterial Agents/administration & dosage
  • Drug Administration Schedule
  • Humans
  • Middle Aged
  • Male
  • Prosthesis-Related Infections/prevention & control
  • Cefuroxime/administration & dosage
  • Microbial Sensitivity Tests
  • Subcutaneous Tissue/metabolism
  • Microdialysis
  • Arthroplasty, Replacement, Knee
  • Aged
  • Antibiotic Prophylaxis/methods
  • Infusions, Intravenous

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