Brain state-dependent peripheral nerve stimulation for plasticity induction in stroke patients

Andrew James Thomas Stevenson, Helle Rovsing Møller Jørgensen, Kåre Eg Severinsen, Susan Aliakbaryhosseinabadi, Ning Jiang, Dario Farina, Natalie Mrachacz-Kersting

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Artificial activation of peripheral afferent fibers, with the resulting sensory feedback timed to arrive at the peak negativity of the movement-related cortical potential, induces significant increases in the excitability of cortical projections to the target muscle in healthy individuals and chronic stroke patients. In the currently ongoing study, we applied this associative brain- computer interface paradigm to sub-acute stroke patients. Compared to a sham group, where the peripheral electrical stimulation intensity was below the acti- vation threshold of the sensory afferents, the associative intervention group displayed substantial increases in corticospinal excitability to the target muscle (tibialis anterior).
Original languageEnglish
Title of host publicationConverging Clinical and Engineering Research on Neurorehabilitation III : Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16–20, 2018, Pisa, Italy
EditorsLorenzo Masia, Silvestro Micera, Metin Akay, José L. Pons
Number of pages5
Publication date2019
ISBN (Print)978-3-030-01844
ISBN (Electronic)978-3-030-01845-0
Publication statusPublished - 2019
EventInternational Conference on Neurorehabilitation - Pisa, Italy
Duration: 16 Oct 201820 Oct 2018


ConferenceInternational Conference on Neurorehabilitation
Internet address
SeriesBiosystems and Biorobotics


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