Brain-state dependent peripheral nerve stimulation for plasticity induction targeting upper-limb

Natalie Mrachacz-Kersting, Strahinja Dosen, Susan Aliakbaryhosseinabadi, Esther M. Pereira, Andrew James Thomas Stevenson, Ning Jiang, Dario Farina

Research output: Contribution to book/anthology/report/conference proceedingArticle in proceedingResearchpeer-review

5 Citations (Scopus)


Brain-computer interfaces have increasingly found applications within the rehabilitation of lost motor function in stroke patients. Most studies have targeted upper limb muscles and used sensorimotor rhythms as the control signal. In a series of studies, we have introduced an associative BCI modeled on known theories of memory and learning that implements the movement related cortical potential (MRCP) as a way to control an external device that provides afferent generated feedback to the user’s brain at the time of the peak negative phase of the MRCP. In its application to lower limb muscles it demonstrates significant plasticity induction that requires no user training. In the current study, we tested if this associative BCI is effective when targeting upper limb muscles. Further, we explored if there is a difference when the MRCP is gen- erated as part of a simple (wrist extension) versus a complex (reach and grasp) movement.
Original languageEnglish
Title of host publicationConverging Clinical and Engineering Research on Neurorehabilitation III : Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16–20, 2018, Pisa, Italy
EditorsLorenzo Masia, Silvestro Micera, Metin Akay, José L. Pons
Number of pages5
Publication date2019
ISBN (Print)978-3-030-01844
ISBN (Electronic)978-3-030-01845-0
Publication statusPublished - 2019
EventInternational Conference on Neurorehabilitation - Pisa, Italy
Duration: 16 Oct 201820 Oct 2018


ConferenceInternational Conference on Neurorehabilitation
Internet address
SeriesBiosystems and Biorobotics


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