CD11c-targeted delivery of DNA to dendritic cells leads to cGAS- and STING-dependent maturation

Marlene Fyrstenberg Laursen, Esben Christensen, Laura L. T. Degn, Kasper Jønsson, Martin R. Jakobsen, Ralf Agger, Emil Kofod-Olsen

Research output: Contribution to journalJournal articleResearchpeer-review

8 Citations (Scopus)
Original languageEnglish
JournalJournal of Immunotherapy
Volume41
Issue number1
Pages (from-to)9-18
Number of pages10
ISSN1524-9557
DOIs
Publication statusPublished - 2018

Keywords

  • Journal Article
  • DC maturation
  • cGAS
  • Antibody-Targeting
  • STING
  • CD11c Antigen/metabolism
  • Nucleotidyltransferases/genetics
  • Programmed Cell Death 1 Receptor/immunology
  • Immunotherapy/methods
  • Humans
  • RNA, Small Interfering/genetics
  • Membrane Proteins/genetics
  • THP-1 Cells
  • Antibodies, Monoclonal/therapeutic use
  • Dendritic Cells/physiology
  • Endocytosis
  • CTLA-4 Antigen/immunology
  • DNA/immunology
  • B7-H1 Antigen/immunology
  • Neoplasms/immunology
  • Cell Differentiation
  • Cytokines/metabolism

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