Abstract
Pancreatic adenocarcinoma has a horrible prognosis, which is partly due to difficulties in diagnosing the disease in an early stage. Additional blood-born biomarkers for pancreatic adenocarcinoma are needed. Epigenetic modifications, as changes in DNA methylation, is a fundamental part of carcinogenesis. The aim of this paper is to do an update on cell-free DNA methylation as blood-based biomarkers for pancreatic adenocarcinoma. The current literature including our studies clearly indicates that cell-free DNA methylation has the potential as blood-based diagnostic and prognostic biomarkers for pancreatic adenocarcinoma. However, still no clinical applicable biomarker for pancreatic adenocarcinoma based on DNA methylation do exist. Further well-designed validation studies are needed.
| Original language | English |
|---|---|
| Article number | 5020008 |
| Journal | Epigenomes |
| Volume | 5 |
| Issue number | 2 |
| ISSN | 2075-4655 |
| DOIs | |
| Publication status | Published - 2021 |
Keywords
- pancreatic cancer
- pancreatic ductal adenocarcinoma
- epigenetic
- DNA methylation
- diagnostic biomarker
- prognostic biomarker
- cell-free DNA