Cell-based therapy for the treatment of female stress urinary incontinence: an early cost–effectiveness analysis

Andreas Westh Vilsbøll, Jakob Munk Mouritsen, Line Park Jensen, Nikolaj Bødker, Annette Willemoes Holst, Cristian Pablo Pennisi, Lars Holger Ehlers

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Abstract

Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.

Original languageEnglish
JournalRegenerative Medicine
Volume13
Issue number3
Pages (from-to)321-330
ISSN1746-0751
DOIs
Publication statusPublished - 1 May 2018

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Stress Urinary Incontinence
Myoblasts
Slings
Cost effectiveness
Cell- and Tissue-Based Therapy
Suburethral Slings
Cost-Benefit Analysis
Costs and Cost Analysis
Decision Trees
Expert Testimony
Therapeutics
Decision trees
Sensitivity analysis
Costs
In Vitro Techniques

Cite this

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title = "Cell-based therapy for the treatment of female stress urinary incontinence: an early cost–effectiveness analysis",
abstract = "Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.",
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Cell-based therapy for the treatment of female stress urinary incontinence : an early cost–effectiveness analysis. / Vilsbøll, Andreas Westh; Mouritsen, Jakob Munk; Jensen, Line Park; Bødker, Nikolaj; Holst, Annette Willemoes; Pennisi, Cristian Pablo; Ehlers, Lars Holger.

In: Regenerative Medicine, Vol. 13, No. 3, 01.05.2018, p. 321-330.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Cell-based therapy for the treatment of female stress urinary incontinence

T2 - an early cost–effectiveness analysis

AU - Vilsbøll, Andreas Westh

AU - Mouritsen, Jakob Munk

AU - Jensen, Line Park

AU - Bødker, Nikolaj

AU - Holst, Annette Willemoes

AU - Pennisi, Cristian Pablo

AU - Ehlers, Lars Holger

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.

AB - Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.

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DO - 10.2217/rme-2017-0124

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VL - 13

SP - 321

EP - 330

JO - Regenerative Medicine

JF - Regenerative Medicine

SN - 1746-0751

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