Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Hakan Erdem, Derya Ozturk-Engin, Yasemin Cag, Seniha Senbayrak, Asuman Inan, Esra Kazak, Nazif Elaldi, Umit Savasci, Haluk Vahaboglu, Rodrigo Hasbun*, ID-IRI study group, Signe Maj Sørensen (Member of study group)

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

21 Citations (Scopus)
167 Downloads (Pure)


Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Pages (from-to)107-109
Number of pages3
Publication statusPublished - 1 Dec 2017


  • CSF
  • Encephalitis
  • Leukocyte
  • Meningitis
  • Pleocytosis


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