TY - JOUR
T1 - Cerebral Microdialysis in Aneurismal Subarachnoid Hemorrhage Patient Reveals a Detrimental Shift in Brain Energy Metabolism, Despite Normal Perfusion Pressure
AU - Nielsen, Frederik
AU - Haure, Pernille
AU - Madsen, Jacob
AU - Steenfeldt Nielsen, Birgitte
AU - Reides Bjarkam, Carsten
PY - 2020/8/24
Y1 - 2020/8/24
N2 - The present case study concerns a patient admitted to our neuro-intensive care unit with a severe aneurismal subarachnoid hemorrhage rebleeding. The patient was equipped with multimodal neuromonitoring, including cerebral microdialysis. During the neuro-intensive care unit, there was a gradual decrease in cerebral perfusion pressure, which was within normally accepted levels, correlated to a detrimental shift in cerebral metabolism, from mitochondrial dysfunction to an ischemic pattern. Subsequently, the clinical and paraclinical status of the patient worsened. The present case highlights how the dynamic assessment of cerebral metabolic patterns and the concept of mitochondrial dysfunction can be relevant in the day-to-day clinical setting, to evaluate and optimize basic, well-known physiological parameters, such as cerebral perfusion pressure.
AB - The present case study concerns a patient admitted to our neuro-intensive care unit with a severe aneurismal subarachnoid hemorrhage rebleeding. The patient was equipped with multimodal neuromonitoring, including cerebral microdialysis. During the neuro-intensive care unit, there was a gradual decrease in cerebral perfusion pressure, which was within normally accepted levels, correlated to a detrimental shift in cerebral metabolism, from mitochondrial dysfunction to an ischemic pattern. Subsequently, the clinical and paraclinical status of the patient worsened. The present case highlights how the dynamic assessment of cerebral metabolic patterns and the concept of mitochondrial dysfunction can be relevant in the day-to-day clinical setting, to evaluate and optimize basic, well-known physiological parameters, such as cerebral perfusion pressure.
KW - CPP
KW - Mitochondrial dysfunction
KW - SAH
UR - http://www.scopus.com/inward/record.url?scp=85091696635&partnerID=8YFLogxK
U2 - 10.3390/metabo10090341
DO - 10.3390/metabo10090341
M3 - Journal article
C2 - 32846990
SN - 2218-1989
VL - 10
SP - 1
EP - 5
JO - Metabolites
JF - Metabolites
IS - 9
M1 - 341
ER -