Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

Susanna Ranta; Ruta Tuckuviene; Anne Mäkipernaa; Birgitte K Albertsen; Tony Frisk; Ulf Tedgård; Olafur G Jónsson; Kaie Pruunsild; Nadine Gretenkort Andersson; Maria Winther Gunnes; Sonata Saulyte Trakymiene; Thomas Frandsen; Mats Heyman; Ellen Ruud; Jon Helgestad

doi:10.1111/bjh.13162

Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

Susanna Ranta, Ruta Tuckuviene, Anne Mäkipernaa, Birgitte K Albertsen, Tony Frisk, Ulf Tedgård, Olafur G Jónsson, Kaie Pruunsild, Nadine Gretenkort Andersson, Maria Winther Gunnes, Sonata Saulyte Trakymiene, Thomas Frandsen, Mats Heyman, Ellen Ruud, Jon Helgestad

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

Abstract

We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

Original language	English
Journal	British Journal of Haematology
Volume	168
Issue number	4
Pages (from-to)	547-552
Number of pages	6
ISSN	0007-1048
DOIs	https://doi.org/10.1111/bjh.13162
Publication status	Published - 2015

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Ranta, S., Tuckuviene, R., Mäkipernaa, A., Albertsen, B. K., Frisk, T., Tedgård, U., Jónsson, O. G., Pruunsild, K., Gretenkort Andersson, N., Winther Gunnes, M., Saulyte Trakymiene, S., Frandsen, T., Heyman, M., Ruud, E., & Helgestad, J. (2015). Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology. British Journal of Haematology, 168(4), 547-552. https://doi.org/10.1111/bjh.13162

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title = "Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology",

abstract = "We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.",

author = "Susanna Ranta and Ruta Tuckuviene and Anne M{\"a}kipernaa and Albertsen, {Birgitte K} and Tony Frisk and Ulf Tedg{\aa}rd and J{\'o}nsson, {Olafur G} and Kaie Pruunsild and {Gretenkort Andersson}, Nadine and {Winther Gunnes}, Maria and {Saulyte Trakymiene}, Sonata and Thomas Frandsen and Mats Heyman and Ellen Ruud and Jon Helgestad",

note = "{\textcopyright} 2014 John Wiley & Sons Ltd.",

year = "2015",

doi = "10.1111/bjh.13162",

language = "English",

volume = "168",

pages = "547--552",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

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Ranta, S, Tuckuviene, R, Mäkipernaa, A, Albertsen, BK, Frisk, T, Tedgård, U, Jónsson, OG, Pruunsild, K, Gretenkort Andersson, N, Winther Gunnes, M, Saulyte Trakymiene, S, Frandsen, T, Heyman, M, Ruud, E & Helgestad, J 2015, 'Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology', British Journal of Haematology, vol. 168, no. 4, pp. 547-552. https://doi.org/10.1111/bjh.13162

Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology. / Ranta, Susanna; Tuckuviene, Ruta; Mäkipernaa, Anne et al.
In: British Journal of Haematology, Vol. 168, No. 4, 2015, p. 547-552.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

AU - Ranta, Susanna

AU - Tuckuviene, Ruta

AU - Mäkipernaa, Anne

AU - Albertsen, Birgitte K

AU - Frisk, Tony

AU - Tedgård, Ulf

AU - Jónsson, Olafur G

AU - Pruunsild, Kaie

AU - Gretenkort Andersson, Nadine

AU - Winther Gunnes, Maria

AU - Saulyte Trakymiene, Sonata

AU - Frandsen, Thomas

AU - Heyman, Mats

AU - Ruud, Ellen

AU - Helgestad, Jon

PY - 2015

Y1 - 2015

N2 - We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

AB - We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

U2 - 10.1111/bjh.13162

DO - 10.1111/bjh.13162

M3 - Journal article

C2 - 25288392

SN - 0007-1048

VL - 168

SP - 547

EP - 552

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

Abstract

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