Abstract
Methods: A random sample was selected for chart-review from a Danish nationwide cohort of patients
Results: 521 were diagnosed in the study period. A random sample of 25% were selected, and 106 charts were possible to retrieve, with 48 chart reviews resulting in confirmation of diagnosis. Time from first reported affective symptoms to diagnosis was 2.6 ± 2.7 years for depressive symptoms, 2.5 ± 2.9 years for mixed symptoms, 1.4 ± 1.6 years for hypomanic symptoms, and 0.4 ± 0.5 years for manic symptoms. A hierarchical clustering analysis revealed three patient-profiles: primarily hypomanic/manic, primarily depressive, and more rare, primarily mixed profile. Frequently reported symptoms prior to diagnosis include anhedonia (79%), irritability (71%), hyperactivity (62.5%), decreased energy (62.5%), and psychotic symptoms (52%).Symptoms of ADHD (19%), comorbid ADHD (15%), symptoms of anxiety (52%), comorbid anxiety (4%), suicidal thoughts (50%), suicide attempts (8%), cutting (23%), substance misuse (21%), and criminal activity (10%) were reported before incident BD diagnosis.
Conclusion: The observed patient-profiles leading to diagnosis were primarily manic or depressive, resembling presentations in adults. The presence of ADHD, anxiety, suicide attempts, cutting, and criminal activity prior to diagnosis emphasizes the need for treatment of children and adolescents with affective symptoms. The gap from appearance of the symptoms to diagnosis suggests a window for earlier treatment.
Original language | English |
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Journal | Nordic Journal of Psychiatry |
Volume | 77 |
Issue number | 3 |
Pages (from-to) | 282-292 |
Number of pages | 11 |
ISSN | 0803-9488 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2022 The Nordic Psychiatric Association.
Keywords
- Bipolar disorder
- characteristics
- pediatric onset
- symptoms
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Dive into the research topics of 'Characteristics prior to and at time of diagnosis in pediatric bipolar disorder'. Together they form a unique fingerprint.Datasets
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Characteristics prior to and at time of diagnosis in pediatric bipolar disorder
Laursen, M. F. (Contributor), Correll, C. U. (Creator), Licht, R. W. (Creator), Rodrigo-Domingo, M. (Creator), Pagsberg, A. K. (Creator) & Nielsen, R. E. (Creator), Taylor & Francis, 11 Jul 2023
DOI: 10.6084/m9.figshare.20286832, https://tandf.figshare.com/articles/dataset/Characteristics_prior_to_and_at_time_of_diagnosis_in_pediatric_bipolar_disorder/20286832
Dataset
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Characteristics prior to and at time of diagnosis in pediatric bipolar disorder
Laursen, M. F. (Contributor), Correll, C. U. (Creator), Licht, R. W. (Creator), Rodrigo-Domingo, M. (Creator), Pagsberg, A. K. (Creator) & Nielsen, R. E. (Creator), Taylor & Francis, 11 Jul 2023
DOI: 10.6084/m9.figshare.20286832.v2, https://tandf.figshare.com/articles/dataset/Characteristics_prior_to_and_at_time_of_diagnosis_in_pediatric_bipolar_disorder/20286832/2
Dataset
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Characteristics prior to and at time of diagnosis in pediatric bipolar disorder
Laursen, M. F. (Contributor), Correll, C. U. (Creator), Licht, R. W. (Creator), Rodrigo-Domingo, M. (Creator), Pagsberg, A. K. (Creator) & Nielsen, R. E. (Creator), Taylor & Francis, 2022
DOI: 10.6084/m9.figshare.20286832.v1, https://tandf.figshare.com/articles/online_resource/Characteristics_prior_to_and_at_time_of_diagnosis_in_pediatric_bipolar_disorder/20286832/1
Dataset