Children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorder share distinct microbiota compositions

Research output: Contribution to journalJournal articleResearchpeer-review

10 Citations (Scopus)
70 Downloads (Pure)

Abstract

An association has been suggested between altered gut microbiota, and attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), respectively. Thus, we analyzed the gut microbiota composition in children and adolescents with or without these disorders and evaluated the systemic effects of these bacteria. We recruited study participants diagnosed with ADHD, ASD, and comorbid ADHD/ASD, while the control groups consisted both of siblings and non-related children. The gut microbiota was analyzed by 16S rRNA gene sequencing of the V4 region, while the concentration of lipopolysaccharide-binding protein (LBP), cytokines, and other signaling molecules were measured in plasma. Importantly the gut microbiota compositions of cases with ADHD and ASD were highly similar for both alpha- and beta-diversity while differing from that of non-related controls. Furthermore, a subset of ADHD and ASD cases had an increased LBP concentration compared to non-affected children, which was positively correlated with interleukin (IL)-8, 12, and 13. These observations indicate disruption of the intestinal barrier and immune dysregulation among the subset of children with ADHD or ASD.
Original languageEnglish
Article number2211923
JournalGut Microbes
Volume15
Issue number1
ISSN1949-0976
DOIs
Publication statusPublished - 2023

Keywords

  • Adolescent
  • Attention Deficit Disorder with Hyperactivity
  • Autism Spectrum Disorder
  • Child
  • Gastrointestinal Microbiome/genetics
  • Humans
  • Microbiota
  • RNA, Ribosomal, 16S/genetics
  • microbiota
  • attention deficit hyperactivity disorder
  • microbiome
  • neurodevelopmental disorders
  • Autism spectrum disorder
  • inflammation
  • gut-brain axis

Fingerprint

Dive into the research topics of 'Children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorder share distinct microbiota compositions'. Together they form a unique fingerprint.

Cite this