Abstract
The use of chimeric virus-like particles represents a new strategy for delivering tumor antigens to the immune system for the initiation of antitumor immune responses. Immunization of DBA/2 mice with the P1A peptide derived from the P815 tumor-associated antigen P1A induced specific T-cell tolerance, resulting in progression of a regressor P815 cell line in all animals. However, immunization with a human papillomavirus type 16 L1 virus- like particle containing the P1A peptide in the absence of adjuvant induced a protective immune response in mice against a lethal tumor challenge with a progressor P815 tumor cell line. Additionally, we demonstrated that these chimeric virus-like particles could be used therapeutically to suppress the growth of established tumors, resulting in a significant survival advantage for chimeric virus-like particle-treated mice compared with untreated control mice. Chimeric virus-like particles can thus be used as a universal delivery vehicle for both tolerizing and antigenic peptides to induce a strong protective and therapeutic antigen-specific antitumor immune response.
Original language | English |
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Journal | Journal of Cellular Biochemistry |
Volume | 73 |
Issue number | 2 |
Pages (from-to) | 145-152 |
Number of pages | 8 |
ISSN | 0730-2312 |
DOIs | |
Publication status | Published - 1 May 1999 |
Externally published | Yes |
Keywords
- Chimeric virus-like particles
- Immunotherapy
- P1A
- P815
- Peptide-induced tolerance