TY - JOUR
T1 - Chronic diseases requiring hospitalization and risk of non-melanoma skin cancers-A population based study from Denmark
AU - Jensen, Annette Ø
AU - Olesen, Anne B
AU - Dethlefsen, Claus
AU - Sørensen, Henrik T
AU - Karagas, Margaret R
PY - 2008
Y1 - 2008
N2 - We examined the associations between chronic diseases requiring hospitalization and the risk of non-melanoma skin cancers (NMSCs) in a population-based case-control study of 4,187 patients diagnosed with a first primary NMSC in 1995 in Denmark. From the National Patient Registry covering all Danish hospitals, we obtained data on hospitalizations with chronic diseases, recorded before the date of NMSC diagnosis. Using incidence density sampling, we selected 10 age-, gender-, and residence-matched controls from the Danish Civil Registration System. We used conditional logistic regression to compute incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Although no overall association was found between basal cell carcinoma (BCC) and hospitalization for chronic diseases, an elevated IRR for BCC was found among patients with connective tissue disease (IRR 1.34 (95% CI: 0.99-1.82)), transplants (IRR 8.00 (95% CI: 2.15-30)), and lymphoma (IRR 2.50 (95% CI: 1.29-4.84)). An overall association between squamous cell carcinoma (SCC) and hospitalization for chronic diseases was found and specific among patients with leukemia (IRR 7.75 (95% CI: 2.35-26)), lymphoma (IRR 3.86 (95% CI: 0.99-15)), and skin diseases (IRR 5.28 (95% CI: 1.95-14)). Our study supports the presence of an association between certain chronic diseases and NMSC, and further suggests that these results unlikely are due to bias.Journal of Investigative Dermatology advance online publication, 4 October 2007; doi:10.1038/sj.jid.5701094.
AB - We examined the associations between chronic diseases requiring hospitalization and the risk of non-melanoma skin cancers (NMSCs) in a population-based case-control study of 4,187 patients diagnosed with a first primary NMSC in 1995 in Denmark. From the National Patient Registry covering all Danish hospitals, we obtained data on hospitalizations with chronic diseases, recorded before the date of NMSC diagnosis. Using incidence density sampling, we selected 10 age-, gender-, and residence-matched controls from the Danish Civil Registration System. We used conditional logistic regression to compute incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Although no overall association was found between basal cell carcinoma (BCC) and hospitalization for chronic diseases, an elevated IRR for BCC was found among patients with connective tissue disease (IRR 1.34 (95% CI: 0.99-1.82)), transplants (IRR 8.00 (95% CI: 2.15-30)), and lymphoma (IRR 2.50 (95% CI: 1.29-4.84)). An overall association between squamous cell carcinoma (SCC) and hospitalization for chronic diseases was found and specific among patients with leukemia (IRR 7.75 (95% CI: 2.35-26)), lymphoma (IRR 3.86 (95% CI: 0.99-15)), and skin diseases (IRR 5.28 (95% CI: 1.95-14)). Our study supports the presence of an association between certain chronic diseases and NMSC, and further suggests that these results unlikely are due to bias.Journal of Investigative Dermatology advance online publication, 4 October 2007; doi:10.1038/sj.jid.5701094.
U2 - 10.1038/sj.jid.5701094
DO - 10.1038/sj.jid.5701094
M3 - Journal article
SN - 0022-202X
VL - 128
SP - 926
EP - 931
JO - The Journal of Investigative Dermatology
JF - The Journal of Investigative Dermatology
ER -