Combining sCD163 with CA 19-9 Increases the Predictiveness of Pancreatic Ductal Adenocarcinoma

Liva K. Stuhr, Kasper Madsen, Astrid Z. Johansen, Inna M. Chen, Carsten P. Hansen, Lars H. Jensen, Torben F. Hansen, Kirstine Kløve-Mogensen, Kaspar R. Nielsen, Julia S. Johansen*

*Corresponding author for this work

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Abstract

The objective of this study was to evaluate the diagnostic and prognostic potential of soluble CD163 (sCD163) in patients with pancreatic ductal adenocarcinoma (PDAC). Preoperative serum samples from 255 patients with PDAC were analyzed for sCD163 using a commercially available enzyme-linked immunosorbent assay. The diagnostic value of sCD163 was evaluated using receiver operating characteristic (ROC) curves. The prognostic significance of sCD163 was evaluated by Cox regression analysis and Kaplan–Meier survival curves. sCD163 was significantly increased in patients with PDAC, across all stages, compared to healthy subjects (stage 1: p value = 0.033; stage 2–4: p value ≤ 0.0001). ROC curves showed that sCD163 combined with CA 19-9 had the highest diagnostic potential compared to sCD163 and CA 19-9 alone both in patients with local PDAC and patients with advanced PDAC. Univariate and multivariate analysis showed no association between sCD163 and overall survival. This study found elevated levels of circulating sCD163 in patients with PDAC, regardless of stage, compared to healthy subjects. This suggests that sCD163 may have a clinical value as a novel diagnostic biomarker in PDAC.

Original languageEnglish
Article number897
JournalCancers
Volume15
Issue number3
Number of pages15
ISSN2072-6694
DOIs
Publication statusPublished - Feb 2023

Keywords

  • biomarker
  • pancreatic cancer
  • soluble CD163
  • tumor-associated macrophages

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