Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events

Celine Petersen, Trine Sørensen, Mikkel Rank Nielsen, Teis Esben Sondergaard, Jens Laurids Sørensen, David Fitzpatrick, Jens Christian Frisvad, Kåre Lehmann Nielsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

4 Citations (Scopus)
36 Downloads (Pure)

Abstract

The Penicillia are known to produce a wide range natural products—some with devastating outcome for the agricultural industry and others with unexploited potential in different applications. However, a large-scale overview of the biosynthetic potential of different species has been lacking. In this study, we sequenced 93 Penicillium isolates and, together with eleven published genomes that hold similar assembly characteristics, we established a species phylogeny as well as defining a Penicillium pangenome. A total of 5612 genes were shared between ≥ 98 isolates corresponding to approximately half of the average number of genes a Penicillium genome holds. We further identified 15 lateral gene transfer events that have occurred in this collection of Penicillium isolates, which might have played an important role, such as niche adaption, in the evolution of these fungi. The comprehensive characterization of the genomic diversity in the Penicillium genus supersedes single-reference genomes, which do not necessarily capture the entire genetic variation.

Original languageEnglish
Article number3
JournalI M A Fungus
Volume14
Issue number1
ISSN2210-6340
DOIs
Publication statusPublished - 1 Feb 2023

Bibliographical note

© 2023. The Author(s).

Keywords

  • Filamentous fungi
  • Lateral gene transfer
  • Long read sequencing
  • MinION
  • Mycotoxins
  • Pangenome
  • Penicillium
  • Phylogenetics

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