Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome

Ulrike Gündel; Stefan Kalkhof; Dimitar Zitzkat; Martin von Bergen; Rolf Altenburger; Eberhard Küster; Martin von Bergen

doi:10.1016/j.ecoenv.2011.10.010

Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome

Ulrike Gündel, Stefan Kalkhof, Dimitar Zitzkat, Martin von Bergen, Rolf Altenburger, Eberhard Küster, Martin von Bergen

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Abstract

Concentration-response experiments, based on the testing of less replicates in favour of more exposure concentrations, represent the typical design of choice applied in toxicological and ecotoxicological effect assessment studies using traditional endpoints such as lethality. However, to our knowledge this concept has not found implementation in the increasingly applied OMICS techniques studying thousands of molecular endpoints at the same time. The present study is among the first applying the concentration-response concept for an ecotoxicoproteomics study. The effects of six different concentrations in the low effect range (

Original language	English
Journal	Ecotoxicology and Environmental Safety
Volume	76
Issue number	2
Pages (from-to)	11-22
Number of pages	12
ISSN	0147-6513
DOIs	https://doi.org/10.1016/j.ecoenv.2011.10.010
Publication status	Published - Feb 2012
Externally published	Yes

Access to Document

10.1016/j.ecoenv.2011.10.010

AUB Link

Search for the material in Aalborg University Library's search engine

Cite this

@article{140ffdb3281d41129f8ffadcc8a0fb03,

title = "Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome",

abstract = "Concentration-response experiments, based on the testing of less replicates in favour of more exposure concentrations, represent the typical design of choice applied in toxicological and ecotoxicological effect assessment studies using traditional endpoints such as lethality. However, to our knowledge this concept has not found implementation in the increasingly applied OMICS techniques studying thousands of molecular endpoints at the same time. The present study is among the first applying the concentration-response concept for an ecotoxicoproteomics study. The effects of six different concentrations in the low effect range (",

author = "Ulrike G{\"u}ndel and Stefan Kalkhof and Dimitar Zitzkat and {von Bergen}, Martin and Rolf Altenburger and Eberhard K{\"u}ster and {von Bergen}, Martin",

year = "2012",

month = feb,

doi = "10.1016/j.ecoenv.2011.10.010",

language = "English",

volume = "76",

pages = "11--22",

journal = "Ecotoxicology and Environmental Safety",

issn = "0147-6513",

publisher = "Academic Press",

number = "2",

}

Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. / Gündel, Ulrike; Kalkhof, Stefan; Zitzkat, Dimitar et al.
In: Ecotoxicology and Environmental Safety, Vol. 76, No. 2, 02.2012, p. 11-22.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Concentration-response concept in ecotoxicoproteomics

T2 - effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome

AU - Gündel, Ulrike

AU - Kalkhof, Stefan

AU - Zitzkat, Dimitar

AU - von Bergen, Martin

AU - Altenburger, Rolf

AU - Küster, Eberhard

AU - von Bergen, Martin

PY - 2012/2

Y1 - 2012/2

N2 - Concentration-response experiments, based on the testing of less replicates in favour of more exposure concentrations, represent the typical design of choice applied in toxicological and ecotoxicological effect assessment studies using traditional endpoints such as lethality. However, to our knowledge this concept has not found implementation in the increasingly applied OMICS techniques studying thousands of molecular endpoints at the same time. The present study is among the first applying the concentration-response concept for an ecotoxicoproteomics study. The effects of six different concentrations in the low effect range (

AB - Concentration-response experiments, based on the testing of less replicates in favour of more exposure concentrations, represent the typical design of choice applied in toxicological and ecotoxicological effect assessment studies using traditional endpoints such as lethality. However, to our knowledge this concept has not found implementation in the increasingly applied OMICS techniques studying thousands of molecular endpoints at the same time. The present study is among the first applying the concentration-response concept for an ecotoxicoproteomics study. The effects of six different concentrations in the low effect range (

U2 - 10.1016/j.ecoenv.2011.10.010

DO - 10.1016/j.ecoenv.2011.10.010

M3 - Journal article

C2 - 22062151

SN - 0147-6513

VL - 76

SP - 11

EP - 22

JO - Ecotoxicology and Environmental Safety

JF - Ecotoxicology and Environmental Safety

IS - 2

ER -

Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome

Abstract

Access to Document

AUB Link

Fingerprint

Cite this