Conditioning pain modulation reduces pain only during the first stmimulation of temporal summation of pain paradigm in healthy participants

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Abstract

BACKGROUND: Pro-nociceptive and anti-nociceptive mechanisms are commonly assessed in clinical and experimental pain studies, while their potential interaction is not well understood.

OBJECTIVES: Investigate the effect of conditioning pain modulation (CPM) on temporal summation of pain (TSP).

METHODS: Twenty healthy participants underwent cuff algometry assessment on the lower legs to establish the pressure pain tolerance threshold (PTT). For the TSP assessment, ten stimuli at the level of the PTT were delivered by computerised cuff inflations (1-s stimulation, 1-s break) while participants rated pain intensity on a 10-cm electronic visual analogue scale (VAS). This TSP paradigm was repeated with a simultaneous conditioning stimulus induced by a cuff on the contralateral leg, inflated to a constant pressure corresponding to 30% (mild), 70% (moderate) or 100% (severe) of the PTT. These were assessed in a randomised order, with a fifteen-minute break between tests and a final TSP test without conditioning was reassessed in the end (post-recording).

RESULTS: An interaction between stimuli (1-10) and repetition (P<0.05) was found for VAS scores. VAS scores for the first stimulus were decreased during 30%, 70%, and 100% conditioning intensities, compared to baseline (P<0.05). There was a significant increase in TSP during conditioning (P<0.05). There were no significant differences between baseline and post-recordings for any stimuli (P>0.05).

CONCLUSIONS: The current study indicates that mild to severe stimuli administered by cuff algometry does not modulate summation effect of temporal summation of pain, which could indicate that pain facilitatory mechanisms are more potent compared with pain inhibitory mechanisms. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalEuropean Journal of Pain
ISSN1090-3801
DOIs
Publication statusE-pub ahead of print - 30 Apr 2019

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Healthy Volunteers
Pain
Pain Threshold
Leg
Conditioning (Psychology)
Pressure
Economic Inflation
Pain Measurement
Visual Analog Scale

Cite this

@article{2d847e97b6d141e8a5a478be5d28fe8d,
title = "Conditioning pain modulation reduces pain only during the first stmimulation of temporal summation of pain paradigm in healthy participants",
abstract = "BACKGROUND: Pro-nociceptive and anti-nociceptive mechanisms are commonly assessed in clinical and experimental pain studies, while their potential interaction is not well understood.OBJECTIVES: Investigate the effect of conditioning pain modulation (CPM) on temporal summation of pain (TSP).METHODS: Twenty healthy participants underwent cuff algometry assessment on the lower legs to establish the pressure pain tolerance threshold (PTT). For the TSP assessment, ten stimuli at the level of the PTT were delivered by computerised cuff inflations (1-s stimulation, 1-s break) while participants rated pain intensity on a 10-cm electronic visual analogue scale (VAS). This TSP paradigm was repeated with a simultaneous conditioning stimulus induced by a cuff on the contralateral leg, inflated to a constant pressure corresponding to 30{\%} (mild), 70{\%} (moderate) or 100{\%} (severe) of the PTT. These were assessed in a randomised order, with a fifteen-minute break between tests and a final TSP test without conditioning was reassessed in the end (post-recording).RESULTS: An interaction between stimuli (1-10) and repetition (P<0.05) was found for VAS scores. VAS scores for the first stimulus were decreased during 30{\%}, 70{\%}, and 100{\%} conditioning intensities, compared to baseline (P<0.05). There was a significant increase in TSP during conditioning (P<0.05). There were no significant differences between baseline and post-recordings for any stimuli (P>0.05).CONCLUSIONS: The current study indicates that mild to severe stimuli administered by cuff algometry does not modulate summation effect of temporal summation of pain, which could indicate that pain facilitatory mechanisms are more potent compared with pain inhibitory mechanisms. This article is protected by copyright. All rights reserved.",
author = "S Holden and Petersen, {K K} and L Arendt-Nielsen and T Graven-Nielsen",
year = "2019",
month = "4",
day = "30",
doi = "10.1002/ejp.1408",
language = "English",
journal = "European Journal of Pain",
issn = "1090-3801",
publisher = "Wiley",

}

TY - JOUR

T1 - Conditioning pain modulation reduces pain only during the first stmimulation of temporal summation of pain paradigm in healthy participants

AU - Holden, S

AU - Petersen, K K

AU - Arendt-Nielsen, L

AU - Graven-Nielsen, T

PY - 2019/4/30

Y1 - 2019/4/30

N2 - BACKGROUND: Pro-nociceptive and anti-nociceptive mechanisms are commonly assessed in clinical and experimental pain studies, while their potential interaction is not well understood.OBJECTIVES: Investigate the effect of conditioning pain modulation (CPM) on temporal summation of pain (TSP).METHODS: Twenty healthy participants underwent cuff algometry assessment on the lower legs to establish the pressure pain tolerance threshold (PTT). For the TSP assessment, ten stimuli at the level of the PTT were delivered by computerised cuff inflations (1-s stimulation, 1-s break) while participants rated pain intensity on a 10-cm electronic visual analogue scale (VAS). This TSP paradigm was repeated with a simultaneous conditioning stimulus induced by a cuff on the contralateral leg, inflated to a constant pressure corresponding to 30% (mild), 70% (moderate) or 100% (severe) of the PTT. These were assessed in a randomised order, with a fifteen-minute break between tests and a final TSP test without conditioning was reassessed in the end (post-recording).RESULTS: An interaction between stimuli (1-10) and repetition (P<0.05) was found for VAS scores. VAS scores for the first stimulus were decreased during 30%, 70%, and 100% conditioning intensities, compared to baseline (P<0.05). There was a significant increase in TSP during conditioning (P<0.05). There were no significant differences between baseline and post-recordings for any stimuli (P>0.05).CONCLUSIONS: The current study indicates that mild to severe stimuli administered by cuff algometry does not modulate summation effect of temporal summation of pain, which could indicate that pain facilitatory mechanisms are more potent compared with pain inhibitory mechanisms. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: Pro-nociceptive and anti-nociceptive mechanisms are commonly assessed in clinical and experimental pain studies, while their potential interaction is not well understood.OBJECTIVES: Investigate the effect of conditioning pain modulation (CPM) on temporal summation of pain (TSP).METHODS: Twenty healthy participants underwent cuff algometry assessment on the lower legs to establish the pressure pain tolerance threshold (PTT). For the TSP assessment, ten stimuli at the level of the PTT were delivered by computerised cuff inflations (1-s stimulation, 1-s break) while participants rated pain intensity on a 10-cm electronic visual analogue scale (VAS). This TSP paradigm was repeated with a simultaneous conditioning stimulus induced by a cuff on the contralateral leg, inflated to a constant pressure corresponding to 30% (mild), 70% (moderate) or 100% (severe) of the PTT. These were assessed in a randomised order, with a fifteen-minute break between tests and a final TSP test without conditioning was reassessed in the end (post-recording).RESULTS: An interaction between stimuli (1-10) and repetition (P<0.05) was found for VAS scores. VAS scores for the first stimulus were decreased during 30%, 70%, and 100% conditioning intensities, compared to baseline (P<0.05). There was a significant increase in TSP during conditioning (P<0.05). There were no significant differences between baseline and post-recordings for any stimuli (P>0.05).CONCLUSIONS: The current study indicates that mild to severe stimuli administered by cuff algometry does not modulate summation effect of temporal summation of pain, which could indicate that pain facilitatory mechanisms are more potent compared with pain inhibitory mechanisms. This article is protected by copyright. All rights reserved.

U2 - 10.1002/ejp.1408

DO - 10.1002/ejp.1408

M3 - Journal article

JO - European Journal of Pain

JF - European Journal of Pain

SN - 1090-3801

ER -