Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid

Jiwei Gu, Rikke Bülow Eschen, Annette Andreasen, Erik Berg Schmidt, Jan Jesper Andreasen, Søren Lundbye-Christensen

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Abstract

Background: Marine omega-3 fatty acids have antiarrhythmic effects, but whether the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) have similar effects is less documented. Some data suggest that intake of ALA may reduce sudden cardiac death (and presumably ventricular arrhythmias) but little is known about a possible effect of ALA on atrial arrhythmias including atrial fibrillation (AF). A possible effect of ALA on AF would probably be caused by incorporation of ALA into atrial tissue.
Aim of study: To compare plasma phospholipid levels of ALA to levels in atrial muscle tissue
Methods: Atrial tissue was obtained from 50 patients during cardiac surgery (valvular surgery and/or coronary artery bypass grafting) and plasma was sampled prior to skin incision. Fatty acid composition was determined in both atrial tissue and plasma phospholipids (49 samples available) by gas chromatography and ALA levels were compared by the Pearson correlation coefficient.
Results: There was a statistical significant correlation (r=0.54, 95% confidence interval: 0.30-0.71) between levels of ALA in plasma phospholipids and atrial tissue.
Conclusion: The content of ALA in plasma phospholipids is a short term indicator of intake of ALA and this correlated well with the content of ALA in atrial tissue. Atrial tissue is not readily available but this study shows that determination of plasma phospholipids may be useful to further investigate an antiarrhythmic effect of ALA on AF.
Original languageEnglish
Publication date5 Sep 2016
Publication statusPublished - 5 Sep 2016
Event12th Congress of the International Society for the Study of Fatty Acids and Lipids - Stellenbosch University, Cape Town, South Africa
Duration: 5 Sep 20169 Sep 2016
Conference number: 12
http://www.issfalcongress.com/

Conference

Conference12th Congress of the International Society for the Study of Fatty Acids and Lipids
Number12
LocationStellenbosch University
Country/TerritorySouth Africa
CityCape Town
Period05/09/201609/09/2016
Internet address

Bibliographical note

Poster nr.. 36

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