CSF biomarker variability in the Alzheimer's Association quality control program

Niklas Mattsson; Ulf Andreasson; Staffan Persson; Maria C Carrillo; Steven Collins; Sonia Chalbot; Neal Cutler; Diane Dufour-Rainfray; Anne M Fagan; Niels Henrik Helweg Heegaard; Ging-Yuek Robin Hsiung; Bradley Hyman; Khalid Iqbal; D Richard Lachno; Alberto Lleó; Piotr Lewczuk; José L Molinuevo; Piero Parchi; Axel Regeniter; Robert Rissman; Hanna Rosenmann; Giuseppe Sancesario; Johannes Schröder; Leslie M Shaw; Charlotte E Teunissen; John Q Trojanowski; Hugo Vanderstichele; Manu Vandijck; Marcel M Verbeek; Henrik Zetterberg; Kaj Blennow; Stephan A Käser; Alzheimer's Association QC Program Work Group

doi:10.1016/j.jalz.2013.01.010

CSF biomarker variability in the Alzheimer's Association quality control program

Niklas Mattsson, Ulf Andreasson, Staffan Persson, Maria C Carrillo, Steven Collins, Sonia Chalbot, Neal Cutler, Diane Dufour-Rainfray, Anne M Fagan, Niels Henrik Helweg Heegaard, Ging-Yuek Robin Hsiung, Bradley Hyman, Khalid Iqbal, D Richard Lachno, Alberto Lleó, Piotr Lewczuk, José L Molinuevo, Piero Parchi, Axel Regeniter, Robert RissmanHanna Rosenmann, Giuseppe Sancesario, Johannes Schröder, Leslie M Shaw, Charlotte E Teunissen, John Q Trojanowski, Hugo Vanderstichele, Manu Vandijck, Marcel M Verbeek, Henrik Zetterberg, Kaj Blennow, Stephan A Käser, Alzheimer's Association QC Program Work Group

Research output: Contribution to journal › Journal article › Research › peer-review

304 Citations (Scopus)

Abstract

The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurements among and within laboratories.

Original language	English
Journal	Alzheimer's & Dementia
Volume	9
Issue number	3
Pages (from-to)	251-261
Number of pages	11
ISSN	1552-5260
DOIs	https://doi.org/10.1016/j.jalz.2013.01.010
Publication status	Published - May 2013
Externally published	Yes

Keywords

Alzheimer Disease
Amyloid beta-Peptides
Biological Markers
Chemistry, Clinical
Enzyme-Linked Immunosorbent Assay
Humans
Laboratories, Hospital
Peptide Fragments
Phosphorylation
Quality Control
Reproducibility of Results
Societies, Medical
tau Proteins

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Mattsson, N., Andreasson, U., Persson, S., Carrillo, M. C., Collins, S., Chalbot, S., Cutler, N., Dufour-Rainfray, D., Fagan, A. M., Heegaard, N. H. H., Robin Hsiung, G-Y., Hyman, B., Iqbal, K., Lachno, D. R., Lleó, A., Lewczuk, P., Molinuevo, J. L., Parchi, P., Regeniter, A., ... Alzheimer's Association QC Program Work Group (2013). CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's & Dementia, 9(3), 251-261. https://doi.org/10.1016/j.jalz.2013.01.010

@article{bb436f5c506e4f8e86140c8c0ce9fee3,

title = "CSF biomarker variability in the Alzheimer's Association quality control program",

abstract = "The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurements among and within laboratories.",

keywords = "Alzheimer Disease, Amyloid beta-Peptides, Biological Markers, Chemistry, Clinical, Enzyme-Linked Immunosorbent Assay, Humans, Laboratories, Hospital, Peptide Fragments, Phosphorylation, Quality Control, Reproducibility of Results, Societies, Medical, tau Proteins",

author = "Niklas Mattsson and Ulf Andreasson and Staffan Persson and Carrillo, {Maria C} and Steven Collins and Sonia Chalbot and Neal Cutler and Diane Dufour-Rainfray and Fagan, {Anne M} and Heegaard, {Niels Henrik Helweg} and {Robin Hsiung}, Ging-Yuek and Bradley Hyman and Khalid Iqbal and Lachno, {D Richard} and Alberto Lle{\'o} and Piotr Lewczuk and Molinuevo, {Jos{\'e} L} and Piero Parchi and Axel Regeniter and Robert Rissman and Hanna Rosenmann and Giuseppe Sancesario and Johannes Schr{\"o}der and Shaw, {Leslie M} and Teunissen, {Charlotte E} and Trojanowski, {John Q} and Hugo Vanderstichele and Manu Vandijck and Verbeek, {Marcel M} and Henrik Zetterberg and Kaj Blennow and K{\"a}ser, {Stephan A} and {Alzheimer's Association QC Program Work Group} and H. Hampel and Aase Handberg and M.T. Heneka and A.Z. Herskovits and S.K. Herukka and D.M. Holtzman and C. Humpel and B.T. Hyman and K. Iqbal and M. Jucker",

year = "2013",

month = may,

doi = "10.1016/j.jalz.2013.01.010",

language = "English",

volume = "9",

pages = "251--261",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

number = "3",

}

Mattsson, N, Andreasson, U, Persson, S, Carrillo, MC, Collins, S, Chalbot, S, Cutler, N, Dufour-Rainfray, D, Fagan, AM, Heegaard, NHH, Robin Hsiung, G-Y, Hyman, B, Iqbal, K, Lachno, DR, Lleó, A, Lewczuk, P, Molinuevo, JL, Parchi, P, Regeniter, A, Rissman, R, Rosenmann, H, Sancesario, G, Schröder, J, Shaw, LM, Teunissen, CE, Trojanowski, JQ, Vanderstichele, H, Vandijck, M, Verbeek, MM, Zetterberg, H, Blennow, K, Käser, SA & Alzheimer's Association QC Program Work Group 2013, 'CSF biomarker variability in the Alzheimer's Association quality control program', Alzheimer's & Dementia, vol. 9, no. 3, pp. 251-261. https://doi.org/10.1016/j.jalz.2013.01.010

TY - JOUR

T1 - CSF biomarker variability in the Alzheimer's Association quality control program

AU - Mattsson, Niklas

AU - Andreasson, Ulf

AU - Persson, Staffan

AU - Carrillo, Maria C

AU - Collins, Steven

AU - Chalbot, Sonia

AU - Cutler, Neal

AU - Dufour-Rainfray, Diane

AU - Fagan, Anne M

AU - Heegaard, Niels Henrik Helweg

AU - Robin Hsiung, Ging-Yuek

AU - Hyman, Bradley

AU - Iqbal, Khalid

AU - Lachno, D Richard

AU - Lleó, Alberto

AU - Lewczuk, Piotr

AU - Molinuevo, José L

AU - Parchi, Piero

AU - Regeniter, Axel

AU - Rissman, Robert

AU - Rosenmann, Hanna

AU - Sancesario, Giuseppe

AU - Schröder, Johannes

AU - Shaw, Leslie M

AU - Teunissen, Charlotte E

AU - Trojanowski, John Q

AU - Vanderstichele, Hugo

AU - Vandijck, Manu

AU - Verbeek, Marcel M

AU - Zetterberg, Henrik

AU - Blennow, Kaj

AU - Käser, Stephan A

AU - Alzheimer's Association QC Program Work Group

AU - Hampel, H.

AU - Handberg, Aase

AU - Heneka, M.T.

AU - Herskovits, A.Z.

AU - Herukka, S.K.

AU - Holtzman, D.M.

AU - Humpel, C.

AU - Hyman, B.T.

AU - Iqbal, K.

AU - Jucker, M.

PY - 2013/5

Y1 - 2013/5

N2 - The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurements among and within laboratories.

AB - The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurements among and within laboratories.

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Biological Markers

KW - Chemistry, Clinical

KW - Enzyme-Linked Immunosorbent Assay

KW - Humans

KW - Laboratories, Hospital

KW - Peptide Fragments

KW - Phosphorylation

KW - Quality Control

KW - Reproducibility of Results

KW - Societies, Medical

KW - tau Proteins

U2 - 10.1016/j.jalz.2013.01.010

DO - 10.1016/j.jalz.2013.01.010

M3 - Journal article

C2 - 23622690

SN - 1552-5260

VL - 9

SP - 251

EP - 261

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 3

ER -

CSF biomarker variability in the Alzheimer's Association quality control program

Abstract

Keywords

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