TY - JOUR
T1 - Cyclic vomiting syndrome and benign paroxysmal torticollis are associated with a high risk of developing primary headache
T2 - A longitudinal study
AU - Moavero, Romina
AU - Papetti, Laura
AU - Bernucci, Maria Chiara
AU - Cenci, Caterina
AU - Ferilli, Michela Ada Noris
AU - Sforza, Giorgia
AU - Vigevano, Federico
AU - Valeriani, Massimiliano
PY - 2019/9
Y1 - 2019/9
N2 - BACKGROUND AND AIM: Episodic syndromes that may be associated with migraine are a group of disorders affecting patients with migraine or with an increased risk of presenting it, and likely represent an early life expression of migraine. Cyclic vomiting syndrome and benign paroxysmal torticollis are well characterized and represent a frequent cause of request for specialist consultations. The aim of this study is to longitudinally assess the rate of headache in patients presenting with cyclic vomiting syndrome and benign paroxysmal torticollis during infancy, and to define the main clinical features of the disorder.METHODS: We administered a questionnaire to the parents of all our pediatric patients with previous diagnosis of cyclic vomiting syndrome and/or benign paroxysmal torticollis according to ICHD-3; questions were focused on the main clinical features of the disorder as well as the prognosis, with particular emphasis on the development of headache.RESULTS: For the final analysis we considered 82 patients with cyclic vomiting syndrome and 33 with benign paroxysmal torticollis. Seventy-nine percent of patients with cyclic vomiting syndrome presented with headache during the follow-up, with a mean age at onset of 6 years; 67% of patients with benign paroxysmal torticollis suffered from headache during the follow-up, with a mean age at onset of 5 years.DISCUSSION: Cyclic vomiting syndrome and benign paroxysmal torticollis are associated with a very high risk of developing headache, mostly migraine, later in life. In both groups of patients, the vast majority presented with different episodic syndromes that may be associated with migraine at different ages, thus suggesting an age-dependent evolution of migraine-like symptoms before the onset of clear migrainous headache.
AB - BACKGROUND AND AIM: Episodic syndromes that may be associated with migraine are a group of disorders affecting patients with migraine or with an increased risk of presenting it, and likely represent an early life expression of migraine. Cyclic vomiting syndrome and benign paroxysmal torticollis are well characterized and represent a frequent cause of request for specialist consultations. The aim of this study is to longitudinally assess the rate of headache in patients presenting with cyclic vomiting syndrome and benign paroxysmal torticollis during infancy, and to define the main clinical features of the disorder.METHODS: We administered a questionnaire to the parents of all our pediatric patients with previous diagnosis of cyclic vomiting syndrome and/or benign paroxysmal torticollis according to ICHD-3; questions were focused on the main clinical features of the disorder as well as the prognosis, with particular emphasis on the development of headache.RESULTS: For the final analysis we considered 82 patients with cyclic vomiting syndrome and 33 with benign paroxysmal torticollis. Seventy-nine percent of patients with cyclic vomiting syndrome presented with headache during the follow-up, with a mean age at onset of 6 years; 67% of patients with benign paroxysmal torticollis suffered from headache during the follow-up, with a mean age at onset of 5 years.DISCUSSION: Cyclic vomiting syndrome and benign paroxysmal torticollis are associated with a very high risk of developing headache, mostly migraine, later in life. In both groups of patients, the vast majority presented with different episodic syndromes that may be associated with migraine at different ages, thus suggesting an age-dependent evolution of migraine-like symptoms before the onset of clear migrainous headache.
KW - Cyclic vomiting syndrome
KW - benign paroxysmal torticollis
KW - episodic syndromes that may be associated with migraine
KW - headache
KW - migraine
KW - pediatric migraine variants
UR - http://www.scopus.com/inward/record.url?scp=85064530306&partnerID=8YFLogxK
U2 - 10.1177/0333102419844542
DO - 10.1177/0333102419844542
M3 - Journal article
C2 - 30982347
SN - 0333-1024
VL - 39
SP - 1236
EP - 1240
JO - Cephalalgia
JF - Cephalalgia
IS - 10
ER -