TY - JOUR
T1 - Danish national guideline for the treatment of Clostridioides difficile infection and use of faecal microbiota transplantation (FMT)
AU - Baunwall, Simon Mark Dahl
AU - Dahlerup, Jens Frederik
AU - Engberg, Jørgen Harald
AU - Erikstrup, Christian
AU - Helms, Morten
AU - Juel, Mie Agerbæk
AU - Kjeldsen, Jens
AU - Nielsen, Hans Linde
AU - Nilsson, Anna Christine
AU - Rode, Anne Abildtrup
AU - Vinter-Jensen, Lars
AU - Hvas, Christian Lodberg
PY - 2021/9
Y1 - 2021/9
N2 - Aim: This Danish national guideline describes the treatment of adult patients with Clostridioides (formerly Clostridium) difficile (CD) infection and the use of faecal microbiota transplantation (FMT). It suggests minimum standard for implementing an FMT service.Method: Four scientific societies appointed members for a working group which conducted a systematic literature review and agreed on the text and recommendations. All clinical recommendations were evalluated for evidence level and grade of recommendation.Results: In CD infection, the use of marketed and experimental antibiotics as well as microbiota-based therapies including FMT are described. An algorithm for evaluating treatment effect is suggested. The organisation of FMT, donor recruitment and screening, laboratory preparation, clinical application and follow-up are described.Conclusion: Updated evidence for the treatment of CD infection and the use of FMT is provided.
AB - Aim: This Danish national guideline describes the treatment of adult patients with Clostridioides (formerly Clostridium) difficile (CD) infection and the use of faecal microbiota transplantation (FMT). It suggests minimum standard for implementing an FMT service.Method: Four scientific societies appointed members for a working group which conducted a systematic literature review and agreed on the text and recommendations. All clinical recommendations were evalluated for evidence level and grade of recommendation.Results: In CD infection, the use of marketed and experimental antibiotics as well as microbiota-based therapies including FMT are described. An algorithm for evaluating treatment effect is suggested. The organisation of FMT, donor recruitment and screening, laboratory preparation, clinical application and follow-up are described.Conclusion: Updated evidence for the treatment of CD infection and the use of FMT is provided.
KW - Clostridioides difficile
KW - fecal microbiota transplantation
UR - http://www.scopus.com/inward/record.url?scp=85110897794&partnerID=8YFLogxK
U2 - 10.1080/00365521.2021.1922749
DO - 10.1080/00365521.2021.1922749
M3 - Journal article
C2 - 34261379
SN - 0036-5521
VL - 56
SP - 1056
EP - 1077
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 9
ER -