Design Principles for Front-End Radical Manufacturing Innovation: Insights from Pharmaceutical Manufacturing

Rasmus Andersen; Casper Schou; Ole Madsen; Astrid Heidemann Lassen; Martin Bieber Jensen; Tristan Schwörer; Bjørn Christian Dueholm; Oline Vinther Olesen

Design Principles for Front-End Radical Manufacturing Innovation: Insights from Pharmaceutical Manufacturing

Rasmus Andersen^*, Casper Schou, Ole Madsen, Astrid Heidemann Lassen, Martin Bieber Jensen, Tristan Schwörer, Bjørn Christian Dueholm, Oline Vinther Olesen

^*Corresponding author for this work

Research output: Contribution to book/anthology/report/conference proceeding › Article in proceeding › Research › peer-review

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Abstract

In response to market shifts, manufacturing companies must innovate their production systems to sustain competitiveness. Incremental changes to production systems fail to address these challenges, necessitating radical innovations in manufacturing. This is particularly evident in the pharmaceutical manufacturing industry, where product shortages and an expanding product variety challenge the traditional mass production paradigm. However, there is a noticeable lack of methods and tools to support the initial stages of manufacturing innovation activities in the pharmaceutical and general manufacturing industries. This paper aims to fill this gap by drawing on insights from a radical manufacturing innovation project in a pharmaceutical manufacturing company. Based on the case study findings, six design principles for front-end radical manufacturing innovation processes and potential supporting tools and activities are proposed.

Original language	English
Title of host publication	Lecture Notes in Mechanical Engineering
Number of pages	10
Publisher	Springer
Pages	1
Publication status	Accepted/In press - Jun 2025

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Andersen et al. (2025) Manufacturing innovation in the front endAccepted author manuscript, 265 KBLicence: CC BY 4.0

AP2030: BRD Aseptic Factory 2030
Madsen, O. (PI), Schou, C. (PI), Schwörer, T. (Project Participant), Jensen, M. B. (Project Participant), Dueholm, B. C. (Project Participant), Rizqi, Z. U. (Project Participant), Andersen, R. (Project Participant) & Chrysostomou, D. (Supervisor)
01/09/2023 → 28/02/2027
Project: Research

Cite this

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title = "Design Principles for Front-End Radical Manufacturing Innovation: Insights from Pharmaceutical Manufacturing",

abstract = "In response to market shifts, manufacturing companies must innovate their production systems to sustain competitiveness. Incremental changes to production systems fail to address these challenges, necessitating radical innovations in manufacturing. This is particularly evident in the pharmaceutical manufacturing industry, where product shortages and an expanding product variety challenge the traditional mass production paradigm. However, there is a noticeable lack of methods and tools to support the initial stages of manufacturing innovation activities in the pharmaceutical and general manufacturing industries. This paper aims to fill this gap by drawing on insights from a radical manufacturing innovation project in a pharmaceutical manufacturing company. Based on the case study findings, six design principles for front-end radical manufacturing innovation processes and potential supporting tools and activities are proposed.",

author = "Rasmus Andersen and Casper Schou and Ole Madsen and Lassen, \{Astrid Heidemann\} and Jensen, \{Martin Bieber\} and Tristan Schw{\"o}rer and Dueholm, \{Bj{\o}rn Christian\} and Olesen, \{Oline Vinther\}",

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AU - Andersen, Rasmus

AU - Schou, Casper

AU - Madsen, Ole

AU - Lassen, Astrid Heidemann

AU - Jensen, Martin Bieber

AU - Schwörer, Tristan

AU - Dueholm, Bjørn Christian

AU - Olesen, Oline Vinther

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N2 - In response to market shifts, manufacturing companies must innovate their production systems to sustain competitiveness. Incremental changes to production systems fail to address these challenges, necessitating radical innovations in manufacturing. This is particularly evident in the pharmaceutical manufacturing industry, where product shortages and an expanding product variety challenge the traditional mass production paradigm. However, there is a noticeable lack of methods and tools to support the initial stages of manufacturing innovation activities in the pharmaceutical and general manufacturing industries. This paper aims to fill this gap by drawing on insights from a radical manufacturing innovation project in a pharmaceutical manufacturing company. Based on the case study findings, six design principles for front-end radical manufacturing innovation processes and potential supporting tools and activities are proposed.

AB - In response to market shifts, manufacturing companies must innovate their production systems to sustain competitiveness. Incremental changes to production systems fail to address these challenges, necessitating radical innovations in manufacturing. This is particularly evident in the pharmaceutical manufacturing industry, where product shortages and an expanding product variety challenge the traditional mass production paradigm. However, there is a noticeable lack of methods and tools to support the initial stages of manufacturing innovation activities in the pharmaceutical and general manufacturing industries. This paper aims to fill this gap by drawing on insights from a radical manufacturing innovation project in a pharmaceutical manufacturing company. Based on the case study findings, six design principles for front-end radical manufacturing innovation processes and potential supporting tools and activities are proposed.

M3 - Article in proceeding

SP - 1

BT - Lecture Notes in Mechanical Engineering

PB - Springer

ER -

Design Principles for Front-End Radical Manufacturing Innovation: Insights from Pharmaceutical Manufacturing

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AP2030: BRD Aseptic Factory 2030

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