Development of microRNA therapeutics is coming of age

Eva van Rooij; Sakari Kauppinen

doi:10.15252/emmm.201100899

Development of microRNA therapeutics is coming of age

Eva van Rooij, Sakari Kauppinen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

Original language	English
Journal	E M B O Molecular Medicine (Online)
Volume	6
Issue number	7
Pages (from-to)	851-864
Number of pages	14
ISSN	1757-4676
DOIs	https://doi.org/10.15252/emmm.201100899
Publication status	Published - 2014

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http://embomolmed.embopress.org/content/6/7/851

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title = "Development of microRNA therapeutics is coming of age",

abstract = "MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.",

author = "{van Rooij}, Eva and Sakari Kauppinen",

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year = "2014",

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AU - Kauppinen, Sakari

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AB - MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

U2 - 10.15252/emmm.201100899

DO - 10.15252/emmm.201100899

M3 - Journal article

C2 - 24935956

SN - 1757-4676

VL - 6

SP - 851

EP - 864

JO - E M B O Molecular Medicine (Online)

JF - E M B O Molecular Medicine (Online)

IS - 7

ER -

Development of microRNA therapeutics is coming of age

Abstract

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