Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population

Dimitrios Chiras; Konstantina Tzika; Haris Kokotas; Samantha C Oliveira; Maria Grigoriadou; Anastasia Kastania; Kleanthi Dima; Maria Stefaniotou; Miltiadis Aspiotis; Michael B Petersen; Christos Kroupis; George Kitsos

Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population

Dimitrios Chiras, Konstantina Tzika, Haris Kokotas, Samantha C Oliveira, Maria Grigoriadou, Anastasia Kastania, Kleanthi Dima, Maria Stefaniotou, Miltiadis Aspiotis, Michael B Petersen, Christos Kroupis, George Kitsos

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Abstract

In the Greek population of Epirus, exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) occur at a high prevalence. In this study, we validate a novel lysyl oxidase-like 1 (LOXL1) genotyping method, investigate the previously reported association of LOXL1 with XFS/XFG, and evaluate apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms as genetic risk factors for both conditions in our population.

Original language	English
Journal	Molecular Vision
Volume	19
Pages (from-to)	1006-16
Number of pages	11
ISSN	1090-0535
Publication status	Published - 2013

Keywords

Aged
Amino Acid Oxidoreductases
Amino Acid Sequence
Apolipoproteins E
Case-Control Studies
Exfoliation Syndrome
Female
Genotyping Techniques
Glaucoma, Open-Angle
Greece
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Molecular Sequence Data
Nucleic Acid Denaturation
Polymorphism, Single Nucleotide
Reproducibility of Results

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Chiras, D., Tzika, K., Kokotas, H., Oliveira, S. C., Grigoriadou, M., Kastania, A., Dima, K., Stefaniotou, M., Aspiotis, M., Petersen, M. B., Kroupis, C., & Kitsos, G. (2013). Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population. Molecular Vision, 19, 1006-16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654845/

@article{63a8ebe07e3e40d680290aed20f41181,

title = "Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population",

abstract = "In the Greek population of Epirus, exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) occur at a high prevalence. In this study, we validate a novel lysyl oxidase-like 1 (LOXL1) genotyping method, investigate the previously reported association of LOXL1 with XFS/XFG, and evaluate apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms as genetic risk factors for both conditions in our population.",

keywords = "Aged, Amino Acid Oxidoreductases, Amino Acid Sequence, Apolipoproteins E, Case-Control Studies, Exfoliation Syndrome, Female, Genotyping Techniques, Glaucoma, Open-Angle, Greece, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2), Molecular Sequence Data, Nucleic Acid Denaturation, Polymorphism, Single Nucleotide, Reproducibility of Results",

author = "Dimitrios Chiras and Konstantina Tzika and Haris Kokotas and Oliveira, {Samantha C} and Maria Grigoriadou and Anastasia Kastania and Kleanthi Dima and Maria Stefaniotou and Miltiadis Aspiotis and Petersen, {Michael B} and Christos Kroupis and George Kitsos",

year = "2013",

language = "English",

volume = "19",

pages = "1006--16",

journal = "Molecular Vision",

issn = "1090-0535",

publisher = "Molecular Vision",

}

Chiras, D, Tzika, K, Kokotas, H, Oliveira, SC, Grigoriadou, M, Kastania, A, Dima, K, Stefaniotou, M, Aspiotis, M, Petersen, MB, Kroupis, C & Kitsos, G 2013, 'Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population', Molecular Vision, vol. 19, pp. 1006-16. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654845/>

TY - JOUR

T1 - Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population

AU - Chiras, Dimitrios

AU - Tzika, Konstantina

AU - Kokotas, Haris

AU - Oliveira, Samantha C

AU - Grigoriadou, Maria

AU - Kastania, Anastasia

AU - Dima, Kleanthi

AU - Stefaniotou, Maria

AU - Aspiotis, Miltiadis

AU - Petersen, Michael B

AU - Kroupis, Christos

AU - Kitsos, George

PY - 2013

Y1 - 2013

N2 - In the Greek population of Epirus, exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) occur at a high prevalence. In this study, we validate a novel lysyl oxidase-like 1 (LOXL1) genotyping method, investigate the previously reported association of LOXL1 with XFS/XFG, and evaluate apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms as genetic risk factors for both conditions in our population.

AB - In the Greek population of Epirus, exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) occur at a high prevalence. In this study, we validate a novel lysyl oxidase-like 1 (LOXL1) genotyping method, investigate the previously reported association of LOXL1 with XFS/XFG, and evaluate apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms as genetic risk factors for both conditions in our population.

KW - Aged

KW - Amino Acid Oxidoreductases

KW - Amino Acid Sequence

KW - Apolipoproteins E

KW - Case-Control Studies

KW - Exfoliation Syndrome

KW - Female

KW - Genotyping Techniques

KW - Glaucoma, Open-Angle

KW - Greece

KW - Humans

KW - Male

KW - Methylenetetrahydrofolate Reductase (NADPH2)

KW - Molecular Sequence Data

KW - Nucleic Acid Denaturation

KW - Polymorphism, Single Nucleotide

KW - Reproducibility of Results

M3 - Journal article

C2 - 23687437

SN - 1090-0535

VL - 19

SP - 1006

EP - 1016

JO - Molecular Vision

JF - Molecular Vision

ER -

Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population

Abstract

Keywords

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