Diagnoses of obstetric and postpartum thyroid disease: a Danish validation study

Anne Myrup Houmøller, Katrine Gerlif, Nanna Maria Uldall Torp, Stine Linding Andersen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Different diagnoses of thyroid disease are available in the 10th International Classification of Diseases (ICD-10), but the validity of diagnoses related to obstetric and postpartum thyroid disease is unknown. This was a retrospective cohort study of all patients in the North Denmark Region with a diagnosis of postpartum thyroiditis (PPT) (ICD-10: O905) from 2016 to 2019 or obstetric thyroid disease in 2019 (ICD-10: O992B (hypothyroidism) or O992C (hyperthyroidism)) registered in the Danish National Hospital Register. Information from nationwide registers and medical records were used to assess the validity. Among patients with an O905-diagnosis (n = 40), abnormal thyroid function test results were seen in all cases. A total of eight patients (20.0%) were positive for thyrotropin receptor antibodies postpartum, however, in low titers, and PPT was verified in 39 of 40 cases (97.5%). Altogether 45 of 50 patients with an O992B-diagnosis (90.0%) correctly had hypothyroidism, whereas hyperthyroidism was found in 25 of 39 patients with an O992C-diagnosis (64.1%). This is the first study to validate ICD-10 diagnoses of obstetric and postpartum thyroid disease. A high validity was seen for PPT (O905) and obstetric hypothyroidism (O992B), whereas for obstetric hyperthyroidism (O992C), the diagnosis could not be verified in one third of the cases.

Original languageEnglish
Article number8777
JournalScientific Reports
Volume14
Number of pages9
ISSN2045-2322
DOIs
Publication statusPublished - 16 Apr 2024

Bibliographical note

© 2024. The Author(s).

Keywords

  • Denmark/epidemiology
  • Female
  • Humans
  • Hyperthyroidism/diagnosis
  • Hypothyroidism/diagnosis
  • Postpartum Period
  • Pregnancy
  • Puerperal Disorders
  • Retrospective Studies
  • Thyroid Diseases/diagnosis

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