Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study

F L Crowe; T J Key; P N Appleby; K Overvad; Erik Berg Schmidt; Rikke Egeberg; A Tjønneland; R Kaaks; B Teucher; H Boeing; C Weikert; A Trichopoulou; V Ouranos; E Valanou; G Masala; S Sieri; S Panico; R Tumino; G Matullo; H B Bueno-de-Mesquita; J M A Boer; J W J Beulens; Y T van der Schouw; J R Quirós; G Buckland; M-J Sánchez; M Dorronsoro; J M Huerta; C Moreno-Iribas; B Hedblad; J H Jansson; P Wennberg; K-T Khaw; N Wareham; P Ferrari; A-K Illner; S-C Chuang; T Norat; J Danesh; E Riboli

doi:10.1038/ejcn.2012.51

Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study

F L Crowe, T J Key, P N Appleby, K Overvad, Erik Berg Schmidt, Rikke Egeberg, A Tjønneland, R Kaaks, B Teucher, H Boeing, C Weikert, A Trichopoulou, V Ouranos, E Valanou, G Masala, S Sieri, S Panico, R Tumino, G Matullo, H B Bueno-de-MesquitaJ M A Boer, J W J Beulens, Y T van der Schouw, J R Quirós, G Buckland, M-J Sánchez, M Dorronsoro, J M Huerta, C Moreno-Iribas, B Hedblad, J H Jansson, P Wennberg, K-T Khaw, N Wareham, P Ferrari, A-K Illner, S-C Chuang, T Norat, J Danesh, E Riboli

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Abstract

Background/objectives:Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study.Subjects/methods:Participants were 306 331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall.Results:After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07).Conclusion:A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.European Journal of Clinical Nutrition advance online publication, 23 May 2012; doi:10.1038/ejcn.2012.51.

Original language	English
Journal	European Journal of Clinical Nutrition
Volume	66
Pages (from-to)	950-956
ISSN	0954-3007
DOIs	https://doi.org/10.1038/ejcn.2012.51
Publication status	Published - Aug 2012
Externally published	Yes

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Crowe, F. L., Key, T. J., Appleby, P. N., Overvad, K., Schmidt, E. B., Egeberg, R., Tjønneland, A., Kaaks, R., Teucher, B., Boeing, H., Weikert, C., Trichopoulou, A., Ouranos, V., Valanou, E., Masala, G., Sieri, S., Panico, S., Tumino, R., Matullo, G., ... Riboli, E. (2012). Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study. European Journal of Clinical Nutrition, 66, 950-956. https://doi.org/10.1038/ejcn.2012.51

@article{0fe0be8865174286951ba2b72e0d2ef3,

title = "Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study",

abstract = "Background/objectives:Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study.Subjects/methods:Participants were 306 331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall.Results:After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07).Conclusion:A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.European Journal of Clinical Nutrition advance online publication, 23 May 2012; doi:10.1038/ejcn.2012.51.",

author = "Crowe, {F L} and Key, {T J} and Appleby, {P N} and K Overvad and Schmidt, {Erik Berg} and Rikke Egeberg and A Tj{\o}nneland and R Kaaks and B Teucher and H Boeing and C Weikert and A Trichopoulou and V Ouranos and E Valanou and G Masala and S Sieri and S Panico and R Tumino and G Matullo and Bueno-de-Mesquita, {H B} and Boer, {J M A} and Beulens, {J W J} and {van der Schouw}, {Y T} and Quir{\'o}s, {J R} and G Buckland and M-J S{\'a}nchez and M Dorronsoro and Huerta, {J M} and C Moreno-Iribas and B Hedblad and Jansson, {J H} and P Wennberg and K-T Khaw and N Wareham and P Ferrari and A-K Illner and S-C Chuang and T Norat and J Danesh and E Riboli",

year = "2012",

month = aug,

doi = "10.1038/ejcn.2012.51",

language = "English",

volume = "66",

pages = "950--956",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "Nature Publishing Group",

}

Crowe, FL, Key, TJ, Appleby, PN, Overvad, K, Schmidt, EB, Egeberg, R, Tjønneland, A, Kaaks, R, Teucher, B, Boeing, H, Weikert, C, Trichopoulou, A, Ouranos, V, Valanou, E, Masala, G, Sieri, S, Panico, S, Tumino, R, Matullo, G, Bueno-de-Mesquita, HB, Boer, JMA, Beulens, JWJ, van der Schouw, YT, Quirós, JR, Buckland, G, Sánchez, M-J, Dorronsoro, M, Huerta, JM, Moreno-Iribas, C, Hedblad, B, Jansson, JH, Wennberg, P, Khaw, K-T, Wareham, N, Ferrari, P, Illner, A-K, Chuang, S-C, Norat, T, Danesh, J & Riboli, E 2012, 'Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study', European Journal of Clinical Nutrition, vol. 66, pp. 950-956. https://doi.org/10.1038/ejcn.2012.51

TY - JOUR

T1 - Dietary fibre intake and ischaemic heart disease mortality

T2 - the European Prospective Investigation into Cancer and Nutrition-Heart study

AU - Crowe, F L

AU - Key, T J

AU - Appleby, P N

AU - Overvad, K

AU - Schmidt, Erik Berg

AU - Egeberg, Rikke

AU - Tjønneland, A

AU - Kaaks, R

AU - Teucher, B

AU - Boeing, H

AU - Weikert, C

AU - Trichopoulou, A

AU - Ouranos, V

AU - Valanou, E

AU - Masala, G

AU - Sieri, S

AU - Panico, S

AU - Tumino, R

AU - Matullo, G

AU - Bueno-de-Mesquita, H B

AU - Boer, J M A

AU - Beulens, J W J

AU - van der Schouw, Y T

AU - Quirós, J R

AU - Buckland, G

AU - Sánchez, M-J

AU - Dorronsoro, M

AU - Huerta, J M

AU - Moreno-Iribas, C

AU - Hedblad, B

AU - Jansson, J H

AU - Wennberg, P

AU - Khaw, K-T

AU - Wareham, N

AU - Ferrari, P

AU - Illner, A-K

AU - Chuang, S-C

AU - Norat, T

AU - Danesh, J

AU - Riboli, E

PY - 2012/8

Y1 - 2012/8

N2 - Background/objectives:Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study.Subjects/methods:Participants were 306 331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall.Results:After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07).Conclusion:A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.European Journal of Clinical Nutrition advance online publication, 23 May 2012; doi:10.1038/ejcn.2012.51.

AB - Background/objectives:Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study.Subjects/methods:Participants were 306 331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall.Results:After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07).Conclusion:A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.European Journal of Clinical Nutrition advance online publication, 23 May 2012; doi:10.1038/ejcn.2012.51.

U2 - 10.1038/ejcn.2012.51

DO - 10.1038/ejcn.2012.51

M3 - Journal article

SN - 0954-3007

VL - 66

SP - 950

EP - 956

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

ER -

Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study

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