Diet-induced obese C57BL/6NTac mice were randomly assigned to 2 groups and treated with a single daily dose (1x109CFU) of L.Rhamnusus (test group) or physiological saline (control group) for 4 weeks. Sperm motility and kinematics were assessed by the Sperm Class Analyzer (SCA).
The control group maintained a raising trend in weight gain leading to a significant difference on week 5 continuing to week 8 whereas the DIO mice in the test group did not gain significant weight after the start of probiotic test. The test group showed a significantly higher progressive motility compared to the control group after 4 weeks of receiving the probiotic treatment.
L.Rhamnusus supplementation demonstrated a higher percentage of progressive sperm, suggesting a possible increase in pregnancy. The effect mechanism of L.Rhamnusus could be either through direct influence on sperm motility or indirectly due to the promotion of weight loss. The latter hypothesis is due to the fact that weight-loss leads to scrotal temperature decrease and hormonal balance affecting sperm kinetics and kinematics during maturation in the epididymis. These hypotheses require further investigation.
|Title of host publication||Final programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark|
|Publisher||International Society of In Vitro Fertilization|
|Publication date||Sep 2015|
|Pages||20, No. P9|
|Publication status||Published - Sep 2015|
|Event|| The World Congress Of In Vitro Fertilization - ISIVF 2015 - Copenhagen, Denmark|
Duration: 27 Sep 2015 → 30 Sep 2015
Conference number: 18
|Conference||The World Congress Of In Vitro Fertilization - ISIVF 2015|
|Period||27/09/2015 → 30/09/2015|