Dietary probiotic supplement positively affects sperm motility in obese murine models

Fereshteh Dardmeh, Hiva Alipour, Parisa Gazerani, Gerhard Van Der Horst, Benedict Kjærgaard, Erik Brandsborg, H. Ingolf Nielsen

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearch


Obesity in adult men in recent years has inconsistently been associated with low semen quality and sub-fecundity. Probiotics have gained high interest as alternatives to pharmacological compounds. However, their possible effect on male fertility has been less investigated. This study aimed at assessing the use of L.Rhamnusus on obese male fertility characteristics. We proposed that this probiotic can not only reduce the weight but in parallel would enhance sperm motility in obese male mice.
Diet-induced obese C57BL/6NTac mice were randomly assigned to 2 groups and treated with a single daily dose (1x109CFU) of L.Rhamnusus (test group) or physiological saline (control group) for 4 weeks. Sperm motility and kinematics were assessed by the Sperm Class Analyzer (SCA).
The control group maintained a raising trend in weight gain leading to a significant difference on week 5 continuing to week 8 whereas the DIO mice in the test group did not gain significant weight after the start of probiotic test. The test group showed a significantly higher progressive motility compared to the control group after 4 weeks of receiving the probiotic treatment.
L.Rhamnusus supplementation demonstrated a higher percentage of progressive sperm, suggesting a possible increase in pregnancy. The effect mechanism of L.Rhamnusus could be either through direct influence on sperm motility or indirectly due to the promotion of weight loss. The latter hypothesis is due to the fact that weight-loss leads to scrotal temperature decrease and hormonal balance affecting sperm kinetics and kinematics during maturation in the epididymis. These hypotheses require further investigation.
Original languageEnglish
Title of host publicationFinal programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark
PublisherInternational Society of In Vitro Fertilization
Publication dateSep 2015
Pages20, No. P9
Publication statusPublished - Sep 2015
Event The World Congress Of In Vitro Fertilization - ISIVF 2015 - Copenhagen, Denmark
Duration: 27 Sep 201530 Sep 2015
Conference number: 18


Conference The World Congress Of In Vitro Fertilization - ISIVF 2015

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