Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations

Mads T Søndergaard, Yingjie Liu, Malene Brohus, Wenting Guo, Alma Nani, Catherine Carvajal, Michael Fill, Michael T Overgaard, S R Wayne Chen

Research output: Contribution to journalJournal articleResearchpeer-review

2 Citations (Scopus)
Original languageEnglish
JournalF E B S Journal
Volume286
Issue number22
Pages (from-to)4554-4578
ISSN1742-464X
DOIs
Publication statusPublished - Nov 2019

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Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
HEK293 Cells
Cardiac Arrhythmias

Bibliographical note

© 2019 Federation of European Biochemical Societies.

Keywords

  • arrhythmia
  • calmodulin
  • intracellular Ca release
  • protein regulation
  • ryanodine receptor

Cite this

Søndergaard, Mads T ; Liu, Yingjie ; Brohus, Malene ; Guo, Wenting ; Nani, Alma ; Carvajal, Catherine ; Fill, Michael ; Overgaard, Michael T ; Chen, S R Wayne. / Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations. In: F E B S Journal. 2019 ; Vol. 286, No. 22. pp. 4554-4578.
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Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations. / Søndergaard, Mads T; Liu, Yingjie; Brohus, Malene; Guo, Wenting; Nani, Alma; Carvajal, Catherine; Fill, Michael; Overgaard, Michael T; Chen, S R Wayne.

In: F E B S Journal, Vol. 286, No. 22, 11.2019, p. 4554-4578.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations

AU - Søndergaard, Mads T

AU - Liu, Yingjie

AU - Brohus, Malene

AU - Guo, Wenting

AU - Nani, Alma

AU - Carvajal, Catherine

AU - Fill, Michael

AU - Overgaard, Michael T

AU - Chen, S R Wayne

N1 - © 2019 Federation of European Biochemical Societies.

PY - 2019/11

Y1 - 2019/11

KW - arrhythmia

KW - calmodulin

KW - intracellular Ca release

KW - protein regulation

KW - ryanodine receptor

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U2 - 10.1111/febs.14969

DO - 10.1111/febs.14969

M3 - Journal article

C2 - 31230402

VL - 286

SP - 4554

EP - 4578

JO - F E B S Journal

JF - F E B S Journal

SN - 1742-464X

IS - 22

ER -