Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials

Camilla Molich Hoff; Pernille Lassen; Jesper Grau Eriksen; Hanne Sand Hansen; Lena Specht; Marie Overgaard; Cai Grau; Jørgen Johansen; Jens Knud Daugaard Bentzen; Lisbeth Andersen; Jan F Evensen; Jens Overgaard

doi:10.3109/0284186X.2011.592650

Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials

Camilla Molich Hoff, Pernille Lassen, Jesper Grau Eriksen, Hanne Sand Hansen, Lena Specht, Marie Overgaard, Cai Grau, Jørgen Johansen, Jens Knud Daugaard Bentzen, Lisbeth Andersen, Jan F Evensen, Jens Overgaard

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Abstract

Patients with head and neck squamous cell carcinoma (HNSCC) and a low level of hemoglobin often have a poor response to radiation that may be related to hypoxia-induced radioresistance. We have previously published the importance of hemoglobin level and the effect of transfusion by the results from the randomized DAHANCA 5 trial, including 414 patients in the analysis. Aim of the current analysis was to gain additional power by adding patients from the continued subrandomization in the DAHANCA 7 trial, now including a total of almost 1200 patients.

Original language	English
Journal	Acta Oncologica
Volume	50
Pages (from-to)	1006-14
Number of pages	9
ISSN	0284-186X
DOIs	https://doi.org/10.3109/0284186X.2011.592650
Publication status	Published - 2011
Externally published	Yes

Keywords

Adult
Aged
Carcinoma, Squamous Cell
Combined Modality Therapy
Erythrocyte Transfusion
Female
Head and Neck Neoplasms
Hemoglobins
Humans
Male
Middle Aged
Nimorazole
Radiotherapy
Survival Analysis

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Hoff, C. M., Lassen, P., Eriksen, J. G., Hansen, H. S., Specht, L., Overgaard, M., Grau, C., Johansen, J., Bentzen, J. K. D., Andersen, L., Evensen, J. F., & Overgaard, J. (2011). Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials. Acta Oncologica, 50, 1006-14. https://doi.org/10.3109/0284186X.2011.592650

@article{6b3ad607da65482e90801a8c505c3e3f,

title = "Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials",

abstract = "Patients with head and neck squamous cell carcinoma (HNSCC) and a low level of hemoglobin often have a poor response to radiation that may be related to hypoxia-induced radioresistance. We have previously published the importance of hemoglobin level and the effect of transfusion by the results from the randomized DAHANCA 5 trial, including 414 patients in the analysis. Aim of the current analysis was to gain additional power by adding patients from the continued subrandomization in the DAHANCA 7 trial, now including a total of almost 1200 patients.",

keywords = "Adult, Aged, Carcinoma, Squamous Cell, Combined Modality Therapy, Erythrocyte Transfusion, Female, Head and Neck Neoplasms, Hemoglobins, Humans, Male, Middle Aged, Nimorazole, Radiotherapy, Survival Analysis",

author = "Hoff, {Camilla Molich} and Pernille Lassen and Eriksen, {Jesper Grau} and Hansen, {Hanne Sand} and Lena Specht and Marie Overgaard and Cai Grau and J{\o}rgen Johansen and Bentzen, {Jens Knud Daugaard} and Lisbeth Andersen and Evensen, {Jan F} and Jens Overgaard",

year = "2011",

doi = "10.3109/0284186X.2011.592650",

language = "English",

volume = "50",

pages = "1006--14",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Taylor & Francis",

}

Hoff, CM, Lassen, P, Eriksen, JG, Hansen, HS, Specht, L, Overgaard, M, Grau, C, Johansen, J, Bentzen, JKD, Andersen, L, Evensen, JF & Overgaard, J 2011, 'Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials', Acta Oncologica, vol. 50, pp. 1006-14. https://doi.org/10.3109/0284186X.2011.592650

TY - JOUR

T1 - Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials

AU - Hoff, Camilla Molich

AU - Lassen, Pernille

AU - Eriksen, Jesper Grau

AU - Hansen, Hanne Sand

AU - Specht, Lena

AU - Overgaard, Marie

AU - Grau, Cai

AU - Johansen, Jørgen

AU - Bentzen, Jens Knud Daugaard

AU - Andersen, Lisbeth

AU - Evensen, Jan F

AU - Overgaard, Jens

PY - 2011

Y1 - 2011

N2 - Patients with head and neck squamous cell carcinoma (HNSCC) and a low level of hemoglobin often have a poor response to radiation that may be related to hypoxia-induced radioresistance. We have previously published the importance of hemoglobin level and the effect of transfusion by the results from the randomized DAHANCA 5 trial, including 414 patients in the analysis. Aim of the current analysis was to gain additional power by adding patients from the continued subrandomization in the DAHANCA 7 trial, now including a total of almost 1200 patients.

AB - Patients with head and neck squamous cell carcinoma (HNSCC) and a low level of hemoglobin often have a poor response to radiation that may be related to hypoxia-induced radioresistance. We have previously published the importance of hemoglobin level and the effect of transfusion by the results from the randomized DAHANCA 5 trial, including 414 patients in the analysis. Aim of the current analysis was to gain additional power by adding patients from the continued subrandomization in the DAHANCA 7 trial, now including a total of almost 1200 patients.

KW - Adult

KW - Aged

KW - Carcinoma, Squamous Cell

KW - Combined Modality Therapy

KW - Erythrocyte Transfusion

KW - Female

KW - Head and Neck Neoplasms

KW - Hemoglobins

KW - Humans

KW - Male

KW - Middle Aged

KW - Nimorazole

KW - Radiotherapy

KW - Survival Analysis

U2 - 10.3109/0284186X.2011.592650

DO - 10.3109/0284186X.2011.592650

M3 - Journal article

SN - 0284-186X

VL - 50

SP - 1006

EP - 1014

JO - Acta Oncologica

JF - Acta Oncologica

ER -

Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials

Abstract

Keywords

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