TY - JOUR
T1 - Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
AU - Polcwiartek, Laura Bech
AU - Smith, P. Brian
AU - Benjamin, Daniel K.
AU - Zimmerman, Kanecia
AU - Love, Alycia
AU - Tiu, Lance
AU - Murray, Sylvia
AU - Kang, Phillip
AU - Ebbesen, Finn
AU - Hagstrøm, Søren
AU - Clark, Reese H.
AU - Greenberg, Rachel G.
PY - 2021
Y1 - 2021
N2 - Objectives: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. Study design: Using a cohort design, we identified term infants evaluated for EOS with blood, cerebrospinal fluid, or urine cultures in 326 NICUs (2011–2016). Using multivariable logistic regression, we investigated the association between EOS and demographic characteristics. Results: Of 142,410 infants, 1197 (0.8%) had EOS, most commonly caused by group B Streptococcus (GBS; 40.6%). Lower EOS risk was associated with low Apgar score, Cesarean delivery, small for gestational age, prenatal antibiotic exposure, and positive or unknown maternal GBS screening result. Increased risk was associated with prolonged rupture of membranes, maternal age <19 years, vasopressor treatment, and ventilator support. Conclusion(s): GBS was the most frequent cause of EOS. Early risk factor recognition may help daily management of term infants in NICUs.
AB - Objectives: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. Study design: Using a cohort design, we identified term infants evaluated for EOS with blood, cerebrospinal fluid, or urine cultures in 326 NICUs (2011–2016). Using multivariable logistic regression, we investigated the association between EOS and demographic characteristics. Results: Of 142,410 infants, 1197 (0.8%) had EOS, most commonly caused by group B Streptococcus (GBS; 40.6%). Lower EOS risk was associated with low Apgar score, Cesarean delivery, small for gestational age, prenatal antibiotic exposure, and positive or unknown maternal GBS screening result. Increased risk was associated with prolonged rupture of membranes, maternal age <19 years, vasopressor treatment, and ventilator support. Conclusion(s): GBS was the most frequent cause of EOS. Early risk factor recognition may help daily management of term infants in NICUs.
UR - http://www.scopus.com/inward/record.url?scp=85092654196&partnerID=8YFLogxK
U2 - 10.1038/s41372-020-00860-3
DO - 10.1038/s41372-020-00860-3
M3 - Journal article
SN - 1476-5543
VL - 41
SP - 157
EP - 163
JO - Journal of Perinatology
JF - Journal of Perinatology
ER -