Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients with In-Hospital Cardiac Arrest: A Randomized Clinical Trial

Lars W. Andersen*, Dan Isbye, Jesper Kjærgaard, Camilla M. Kristensen, Søren Darling, Stine T. Zwisler, Stine Fisker, Jens Christian Schmidt, Hans Kirkegaard, Anders M. Grejs, Jørgen R.G. Rossau, Jacob M. Larsen, Bodil S. Rasmussen, Signe Riddersholm, Kasper Iversen, Martin Schultz, Jakob L. Nielsen, Bo Løfgren, Kasper G. Lauridsen, Christoffer SøllingKim Pælestik, Anders G. Kjærgaard, Dorte Due-Rasmussen, Fredrik Folke, Mette G. Charlot, Rikke Malene H.G. Jepsen, Sebastian Wiberg, Michael Donnino, Tobias Kurth, Maria Høybye, Birthe Sindberg, Mathias J. Holmberg, Asger Granfeldt

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

3 Citations (Scopus)
Original languageEnglish
JournalJAMA : the journal of the American Medical Association
Volume326
Issue number16
Pages (from-to)1586-1594
Number of pages9
ISSN0098-7484
DOIs
Publication statusPublished - 26 Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 American Medical Association. All rights reserved.

Keywords

  • Aged
  • Cardiovascular Agents/adverse effects
  • Confidence Intervals
  • Denmark
  • Double-Blind Method
  • Epinephrine/administration & dosage
  • Female
  • Glucocorticoids/administration & dosage
  • Heart Arrest
  • Humans
  • Hyperglycemia/epidemiology
  • Hyponatremia/epidemiology
  • Male
  • Methylprednisolone/administration & dosage
  • Neurologic Examination
  • Placebos/pharmacology
  • Return of Spontaneous Circulation/drug effects
  • Treatment Outcome
  • Uncertainty
  • Vasoconstrictor Agents/administration & dosage
  • Vasopressins/administration & dosage

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