Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review

Randi Tobberup; Lene Thoresen; Ursula G Falkmer; Mette K Yilmaz; Tora S Solheim; Trude R Balstad

doi:10.1016/j.critrevonc.2019.04.014

Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review

Randi Tobberup, Lene Thoresen, Ursula G Falkmer, Mette K Yilmaz, Tora S Solheim, Trude R Balstad

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

212 Downloads (Pure)

Abstract

BACKGROUND: The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer.

METHODS: This review was conducted according to the PRISMA guidelines (PROSPERO ID: 4201707915).

RESULTS: Two underpowered randomized controlled trials and six observational studies were retrieved (n = 894 patients). Health-related quality of life and physical function may improve during anti-neoplastic treatment in who PN treatment is the only feeding opportunity, but not necessarily in patients able to feed enterally. Nutritional status may improve in patients regardless of anti-neoplastic treatment and gastrointestinal function. PN treatment was neither superior to fluid in terminal patients nor to dietary counselling in patients able to feed enterally in regards to survival. The total incidence of adverse events was low.

CONCLUSION: Current PN treatment in patients with advanced cancer is understudied and the level of evidence is weak.

Original language	English
Journal	Critical Reviews in Oncology/Hematology
Volume	139
Pages (from-to)	96-107
Number of pages	12
ISSN	1040-8428
DOIs	https://doi.org/10.1016/j.critrevonc.2019.04.014
Publication status	Published - Jul 2019

Keywords

Cachexia
Intravenous nutrition
Palliative care
Performance status
Supportive care
Weight loss

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10.1016/j.critrevonc.2019.04.014

Effects-of-current-parenteral-nutrition-treatment-on-health-_2019_Critical-RAccepted author manuscript, 586 KBLicence: CC BY-NC-ND 4.0

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Tobberup, R., Thoresen, L., Falkmer, U. G., Yilmaz, M. K., Solheim, T. S., & Balstad, T. R. (2019). Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review. Critical Reviews in Oncology/Hematology, 139, 96-107. https://doi.org/10.1016/j.critrevonc.2019.04.014

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title = "Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review",

abstract = "BACKGROUND: The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer.METHODS: This review was conducted according to the PRISMA guidelines (PROSPERO ID: 4201707915).RESULTS: Two underpowered randomized controlled trials and six observational studies were retrieved (n = 894 patients). Health-related quality of life and physical function may improve during anti-neoplastic treatment in who PN treatment is the only feeding opportunity, but not necessarily in patients able to feed enterally. Nutritional status may improve in patients regardless of anti-neoplastic treatment and gastrointestinal function. PN treatment was neither superior to fluid in terminal patients nor to dietary counselling in patients able to feed enterally in regards to survival. The total incidence of adverse events was low.CONCLUSION: Current PN treatment in patients with advanced cancer is understudied and the level of evidence is weak.",

keywords = "Cachexia, Intravenous nutrition, Palliative care, Performance status, Supportive care, Weight loss",

author = "Randi Tobberup and Lene Thoresen and Falkmer, \{Ursula G\} and Yilmaz, \{Mette K\} and Solheim, \{Tora S\} and Balstad, \{Trude R\}",

year = "2019",

month = jul,

doi = "10.1016/j.critrevonc.2019.04.014",

language = "English",

volume = "139",

pages = "96--107",

journal = "Critical Reviews in Oncology/Hematology",

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publisher = "Elsevier",

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Tobberup, R, Thoresen, L, Falkmer, UG , Yilmaz, MK, Solheim, TS & Balstad, TR 2019, 'Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review', Critical Reviews in Oncology/Hematology, vol. 139, pp. 96-107. https://doi.org/10.1016/j.critrevonc.2019.04.014

Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review. / Tobberup, Randi; Thoresen, Lene; Falkmer, Ursula G et al.
In: Critical Reviews in Oncology/Hematology, Vol. 139, 07.2019, p. 96-107.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer

T2 - A systematic literature review

AU - Tobberup, Randi

AU - Thoresen, Lene

AU - Falkmer, Ursula G

AU - Yilmaz, Mette K

AU - Solheim, Tora S

AU - Balstad, Trude R

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND: The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer.METHODS: This review was conducted according to the PRISMA guidelines (PROSPERO ID: 4201707915).RESULTS: Two underpowered randomized controlled trials and six observational studies were retrieved (n = 894 patients). Health-related quality of life and physical function may improve during anti-neoplastic treatment in who PN treatment is the only feeding opportunity, but not necessarily in patients able to feed enterally. Nutritional status may improve in patients regardless of anti-neoplastic treatment and gastrointestinal function. PN treatment was neither superior to fluid in terminal patients nor to dietary counselling in patients able to feed enterally in regards to survival. The total incidence of adverse events was low.CONCLUSION: Current PN treatment in patients with advanced cancer is understudied and the level of evidence is weak.

AB - BACKGROUND: The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer.METHODS: This review was conducted according to the PRISMA guidelines (PROSPERO ID: 4201707915).RESULTS: Two underpowered randomized controlled trials and six observational studies were retrieved (n = 894 patients). Health-related quality of life and physical function may improve during anti-neoplastic treatment in who PN treatment is the only feeding opportunity, but not necessarily in patients able to feed enterally. Nutritional status may improve in patients regardless of anti-neoplastic treatment and gastrointestinal function. PN treatment was neither superior to fluid in terminal patients nor to dietary counselling in patients able to feed enterally in regards to survival. The total incidence of adverse events was low.CONCLUSION: Current PN treatment in patients with advanced cancer is understudied and the level of evidence is weak.

KW - Cachexia

KW - Intravenous nutrition

KW - Palliative care

KW - Performance status

KW - Supportive care

KW - Weight loss

UR - https://www.scopus.com/pages/publications/85066070812

U2 - 10.1016/j.critrevonc.2019.04.014

DO - 10.1016/j.critrevonc.2019.04.014

M3 - Review article

C2 - 31150954

SN - 1040-8428

VL - 139

SP - 96

EP - 107

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

ER -

Tobberup R, Thoresen L, Falkmer UG , Yilmaz MK, Solheim TS, Balstad TR. Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review. Critical Reviews in Oncology/Hematology. 2019 Jul;139:96-107. Epub 2019 Apr 20. doi: 10.1016/j.critrevonc.2019.04.014

Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review

Abstract

Keywords

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