Effects of marine n-3 fatty acid supplementation in renal transplantation: a randomized controlled trial

Ivar A Eide, Finn P Reinholt, Trond Jenssen, Anders Hartmann, Erik B Schmidt, Anders Åsberg, Stein Bergan, Knut Brabrand, My Svensson

Research output: Contribution to journalJournal articleResearchpeer-review

16 Citations (Scopus)
183 Downloads (Pure)

Abstract

Marine n-3 fatty acids (FAs) may exert beneficial effects on inflammation, fibrosis, and endothelial function, which could preserve renal graft function. In this randomized controlled trial, 132 Norwegian renal transplant recipients received either 2.6 g of marine n-3 FAs or olive oil (control) daily for 44 weeks, in addition to standard care. Thirty patients did not complete the trial. The primary endpoint was change (Δ) in measured glomerular filtration rate (mGFR) during follow-up. We found no significant difference in Δ mGFR between the marine n-3 FA group and controls (6.7 vs 3.8 mL/min/1.73 m2 , p=0.15). Significant beneficial effects from marine n-3 FA supplementation were, however, seen in secondary endpoints plasma triglycerides, plasma high-sensitivity C-reactive protein and brachial artery flow mediated dilation. In the per-protocol population, also the renal graft indices percent interstitial fibrosis and Chronic Allograft Damage Index were significantly lower in the marine n-3 FA group. The cumulative incidence of adverse events did not differ between the marine n-3 FA group (n=218) and controls (n=240). In conclusion, marine FA supplementation did not improve renal function compared with controls, but was safe, lowered plasma triglyceride and high-sensitivity C-reactive protein levels and improved endothelial function. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalAmerican Journal of Transplantation
Volume19
Issue number3
Pages (from-to)790-800
Number of pages11
ISSN1600-6135
DOIs
Publication statusPublished - Mar 2019

Bibliographical note

© 2018 The American Society of Transplantation and the American Society of Transplant Surgeons.

Keywords

  • clinical research/practice
  • interstitial fibrosis and tubular atrophy
  • kidney (allograft) function/dysfunction
  • kidney transplantation/nephrology
  • nutrition
  • pathology/histopathology
  • vascular biology

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