Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma

Hiromichi Sato; Tomoaki Hara; Shotaro Tatekawa; Kazuki Sasaki; Shogo Kobayashi; Toru Kitagawa; Yuichiro Doki; Hidetoshi Eguchi; Kazuhiko Ogawa; Shizuka Uchida; Hideshi Ishii

doi:10.3389/fphys.2022.1025923

Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma

Hiromichi Sato, Tomoaki Hara, Shotaro Tatekawa, Kazuki Sasaki, Shogo Kobayashi, Toru Kitagawa, Yuichiro Doki, Hidetoshi Eguchi, Kazuhiko Ogawa, Shizuka Uchida, Hideshi Ishii

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Abstract

An international project on the human genome revealed that various RNAs (e.g., messenger RNAs, microRNAs, and long noncoding RNAs [lncRNAs] and their subclass circular RNA [circRNA)) are involved in the pathogenesis of different human diseases, including cancer. Recent studies have highlighted the critical roles of lncRNAs and circRNA in pancreatic ductal adenocarcinoma (PDAC), especially in the epithelial–mesenchymal transition, a phenomenon regulating cancer metastasis. Growing research in this field has indicated that the tertiary structure of lncRNAs supposedly regulates biological function via RNA–RNA or RNA–protein associations, aiding early diagnosis and therapy selection for various diseases, including cancer. Here we describe the emerging roles of ncRNAs in PDAC and highlight how these ncRNAs can be used to detect and control this intractable cancer.

Original language	English
Journal	Frontiers in Physiology
Volume	13
ISSN	1664-042X
DOIs	https://doi.org/10.3389/fphys.2022.1025923
Publication status	Published - 14 Nov 2022

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10.3389/fphys.2022.1025923Licence: CC BY 4.0

Sato et al (2022) Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinomaFinal published version, 818 KBLicence: CC BY 4.0

https://www.frontiersin.org/articles/10.3389/fphys.2022.1025923

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title = "Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma",

abstract = "An international project on the human genome revealed that various RNAs (e.g., messenger RNAs, microRNAs, and long noncoding RNAs [lncRNAs] and their subclass circular RNA [circRNA)) are involved in the pathogenesis of different human diseases, including cancer. Recent studies have highlighted the critical roles of lncRNAs and circRNA in pancreatic ductal adenocarcinoma (PDAC), especially in the epithelial–mesenchymal transition, a phenomenon regulating cancer metastasis. Growing research in this field has indicated that the tertiary structure of lncRNAs supposedly regulates biological function via RNA–RNA or RNA–protein associations, aiding early diagnosis and therapy selection for various diseases, including cancer. Here we describe the emerging roles of ncRNAs in PDAC and highlight how these ncRNAs can be used to detect and control this intractable cancer.",

author = "Hiromichi Sato and Tomoaki Hara and Shotaro Tatekawa and Kazuki Sasaki and Shogo Kobayashi and Toru Kitagawa and Yuichiro Doki and Hidetoshi Eguchi and Kazuhiko Ogawa and Shizuka Uchida and Hideshi Ishii",

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doi = "10.3389/fphys.2022.1025923",

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TY - JOUR

T1 - Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma

AU - Sato, Hiromichi

AU - Hara, Tomoaki

AU - Tatekawa, Shotaro

AU - Sasaki, Kazuki

AU - Kobayashi, Shogo

AU - Kitagawa, Toru

AU - Doki, Yuichiro

AU - Eguchi, Hidetoshi

AU - Ogawa, Kazuhiko

AU - Uchida, Shizuka

AU - Ishii, Hideshi

PY - 2022/11/14

Y1 - 2022/11/14

N2 - An international project on the human genome revealed that various RNAs (e.g., messenger RNAs, microRNAs, and long noncoding RNAs [lncRNAs] and their subclass circular RNA [circRNA)) are involved in the pathogenesis of different human diseases, including cancer. Recent studies have highlighted the critical roles of lncRNAs and circRNA in pancreatic ductal adenocarcinoma (PDAC), especially in the epithelial–mesenchymal transition, a phenomenon regulating cancer metastasis. Growing research in this field has indicated that the tertiary structure of lncRNAs supposedly regulates biological function via RNA–RNA or RNA–protein associations, aiding early diagnosis and therapy selection for various diseases, including cancer. Here we describe the emerging roles of ncRNAs in PDAC and highlight how these ncRNAs can be used to detect and control this intractable cancer.

AB - An international project on the human genome revealed that various RNAs (e.g., messenger RNAs, microRNAs, and long noncoding RNAs [lncRNAs] and their subclass circular RNA [circRNA)) are involved in the pathogenesis of different human diseases, including cancer. Recent studies have highlighted the critical roles of lncRNAs and circRNA in pancreatic ductal adenocarcinoma (PDAC), especially in the epithelial–mesenchymal transition, a phenomenon regulating cancer metastasis. Growing research in this field has indicated that the tertiary structure of lncRNAs supposedly regulates biological function via RNA–RNA or RNA–protein associations, aiding early diagnosis and therapy selection for various diseases, including cancer. Here we describe the emerging roles of ncRNAs in PDAC and highlight how these ncRNAs can be used to detect and control this intractable cancer.

U2 - 10.3389/fphys.2022.1025923

DO - 10.3389/fphys.2022.1025923

M3 - Journal article

C2 - 36452037

VL - 13

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

ER -

Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma

Abstract

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