Epidemiological study of venous thromboembolism in a big Danish cohort

Marianne Tang Severinsen, Søren Risom Kristensen, Kim Overvad, Claus Dethlefsen

Research output: Contribution to conference without publisher/journalPosterResearch

Abstract

Introduction: Epidemiological data on venous thromboembolism (VT), i.e. pulmonary emboli (PE) and deep venous thrombosis (DVT) are sparse. We have examined VT-diagnoses registered in a big Danish Cohort study.  Methods: All first-time VT diagnoses in The Danish National Patient Register were identified among participants in the Danish cohort study "Diet, Cancer and Health" in which 57,053 50-64 years old persons were included 1993-7. Medical records were retrieved and reviewed by an experienced physician using a detailed standardized form, and information on the diagnostic work-up and presence of established risk factors including cancer, recent surgery, medical diseases, etc. were registered.  Results: 1,133 patients were registered with a first time diagnoses of venous thrombosis. Of these 1,082 medical records were retrieved and only for 614 patients the diagnoses could be confirmed (56.8%), 18 were probable cases (1.7%) whereas for 449 (41.6%) the diagnosis could be excluded. The incidence rate was 1 per 1000 personyears. Out of the 632 cases 60% were DVT and 40% PE. 315 VT were considered idiopathic (49.8%), 311 were secondary (49.2%) and 15 were unclassifiable. 122 patients had cancer, 87 VT occurred postoperatively (25 had both cancer and operation) and 56 had medical disease (no cancer, no operation) - this corresponds to 39%, 28% and 18%, resp., of secondary VT.  Conclusions: Diagnoses of venous thrombosis registered in routine hospital discharge registries was only correct for about 60% of those registered. About 50% of the first-time venous thrombosis among 50-70 years old study participants is secondary primarily to cancer, surgery and medical diseases.
Original languageEnglish
Publication date2007
Number of pages1
Publication statusPublished - 2007
EventXXIst Congress of the International Society on Thrombosis and Haemostasis - Geneva, Switzerland
Duration: 6 Jul 200712 Jul 2007

Conference

ConferenceXXIst Congress of the International Society on Thrombosis and Haemostasis
CountrySwitzerland
CityGeneva
Period06/07/200712/07/2007

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Venous Thromboembolism
Epidemiologic Studies
Venous Thrombosis
Neoplasms
Embolism
Medical Records
Cohort Studies
Lung
Registries
Diet
Physicians
Incidence
Health

Cite this

Severinsen, M. T., Kristensen, S. R., Overvad, K., & Dethlefsen, C. (2007). Epidemiological study of venous thromboembolism in a big Danish cohort. Poster session presented at XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland.
Severinsen, Marianne Tang ; Kristensen, Søren Risom ; Overvad, Kim ; Dethlefsen, Claus. / Epidemiological study of venous thromboembolism in a big Danish cohort. Poster session presented at XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland.1 p.
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abstract = "Introduction: Epidemiological data on venous thromboembolism (VT), i.e. pulmonary emboli (PE) and deep venous thrombosis (DVT) are sparse. We have examined VT-diagnoses registered in a big Danish Cohort study.  Methods: All first-time VT diagnoses in The Danish National Patient Register were identified among participants in the Danish cohort study {"}Diet, Cancer and Health{"} in which 57,053 50-64 years old persons were included 1993-7. Medical records were retrieved and reviewed by an experienced physician using a detailed standardized form, and information on the diagnostic work-up and presence of established risk factors including cancer, recent surgery, medical diseases, etc. were registered.  Results: 1,133 patients were registered with a first time diagnoses of venous thrombosis. Of these 1,082 medical records were retrieved and only for 614 patients the diagnoses could be confirmed (56.8{\%}), 18 were probable cases (1.7{\%}) whereas for 449 (41.6{\%}) the diagnosis could be excluded. The incidence rate was 1 per 1000 personyears. Out of the 632 cases 60{\%} were DVT and 40{\%} PE. 315 VT were considered idiopathic (49.8{\%}), 311 were secondary (49.2{\%}) and 15 were unclassifiable. 122 patients had cancer, 87 VT occurred postoperatively (25 had both cancer and operation) and 56 had medical disease (no cancer, no operation) - this corresponds to 39{\%}, 28{\%} and 18{\%}, resp., of secondary VT.  Conclusions: Diagnoses of venous thrombosis registered in routine hospital discharge registries was only correct for about 60{\%} of those registered. About 50{\%} of the first-time venous thrombosis among 50-70 years old study participants is secondary primarily to cancer, surgery and medical diseases.",
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Severinsen, MT, Kristensen, SR, Overvad, K & Dethlefsen, C 2007, 'Epidemiological study of venous thromboembolism in a big Danish cohort', Geneva, Switzerland, 06/07/2007 - 12/07/2007, .

Epidemiological study of venous thromboembolism in a big Danish cohort. / Severinsen, Marianne Tang; Kristensen, Søren Risom; Overvad, Kim; Dethlefsen, Claus.

2007. Poster session presented at XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland.

Research output: Contribution to conference without publisher/journalPosterResearch

TY - CONF

T1 - Epidemiological study of venous thromboembolism in a big Danish cohort

AU - Severinsen, Marianne Tang

AU - Kristensen, Søren Risom

AU - Overvad, Kim

AU - Dethlefsen, Claus

N1 - Titel på proceedings: ISTH 2007 Posters CD Rom Oversat titel på proceedings: ISTH 2007 Posters CD Rom

PY - 2007

Y1 - 2007

N2 - Introduction: Epidemiological data on venous thromboembolism (VT), i.e. pulmonary emboli (PE) and deep venous thrombosis (DVT) are sparse. We have examined VT-diagnoses registered in a big Danish Cohort study.  Methods: All first-time VT diagnoses in The Danish National Patient Register were identified among participants in the Danish cohort study "Diet, Cancer and Health" in which 57,053 50-64 years old persons were included 1993-7. Medical records were retrieved and reviewed by an experienced physician using a detailed standardized form, and information on the diagnostic work-up and presence of established risk factors including cancer, recent surgery, medical diseases, etc. were registered.  Results: 1,133 patients were registered with a first time diagnoses of venous thrombosis. Of these 1,082 medical records were retrieved and only for 614 patients the diagnoses could be confirmed (56.8%), 18 were probable cases (1.7%) whereas for 449 (41.6%) the diagnosis could be excluded. The incidence rate was 1 per 1000 personyears. Out of the 632 cases 60% were DVT and 40% PE. 315 VT were considered idiopathic (49.8%), 311 were secondary (49.2%) and 15 were unclassifiable. 122 patients had cancer, 87 VT occurred postoperatively (25 had both cancer and operation) and 56 had medical disease (no cancer, no operation) - this corresponds to 39%, 28% and 18%, resp., of secondary VT.  Conclusions: Diagnoses of venous thrombosis registered in routine hospital discharge registries was only correct for about 60% of those registered. About 50% of the first-time venous thrombosis among 50-70 years old study participants is secondary primarily to cancer, surgery and medical diseases.

AB - Introduction: Epidemiological data on venous thromboembolism (VT), i.e. pulmonary emboli (PE) and deep venous thrombosis (DVT) are sparse. We have examined VT-diagnoses registered in a big Danish Cohort study.  Methods: All first-time VT diagnoses in The Danish National Patient Register were identified among participants in the Danish cohort study "Diet, Cancer and Health" in which 57,053 50-64 years old persons were included 1993-7. Medical records were retrieved and reviewed by an experienced physician using a detailed standardized form, and information on the diagnostic work-up and presence of established risk factors including cancer, recent surgery, medical diseases, etc. were registered.  Results: 1,133 patients were registered with a first time diagnoses of venous thrombosis. Of these 1,082 medical records were retrieved and only for 614 patients the diagnoses could be confirmed (56.8%), 18 were probable cases (1.7%) whereas for 449 (41.6%) the diagnosis could be excluded. The incidence rate was 1 per 1000 personyears. Out of the 632 cases 60% were DVT and 40% PE. 315 VT were considered idiopathic (49.8%), 311 were secondary (49.2%) and 15 were unclassifiable. 122 patients had cancer, 87 VT occurred postoperatively (25 had both cancer and operation) and 56 had medical disease (no cancer, no operation) - this corresponds to 39%, 28% and 18%, resp., of secondary VT.  Conclusions: Diagnoses of venous thrombosis registered in routine hospital discharge registries was only correct for about 60% of those registered. About 50% of the first-time venous thrombosis among 50-70 years old study participants is secondary primarily to cancer, surgery and medical diseases.

M3 - Poster

ER -

Severinsen MT, Kristensen SR, Overvad K, Dethlefsen C. Epidemiological study of venous thromboembolism in a big Danish cohort. 2007. Poster session presented at XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland.